PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21497036-9	2011	This established method was employed to evaluate the inhibitory effects of five target compounds including amitriptyline, hecogenin, imipramine, lamotrigine, and trifluoperazine on enzymatic activity of UGT2B10.	Imipramine	133-143	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	203-210	
23611809-9	2013	Kinetic analyses revealed that the affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher.	Imipramine	88-98	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	61-68	
23611809-4	2013	Using recombinant UGT2B10, we found that it catalyzes the N-glucuronidation of amitriptyline, imipramine, ketotifen, pizotifen, olanzapine, diphenhydramine, tamoxifen, ketoconazole, and midazolam.	Imipramine	94-104	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	18-25	
20133892-0	2010	Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine.	Imipramine	88-98	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	14-21	
20133892-2	2010	The apparent K(m) (S(50)) values for the formation of quaternary N-glucuronides of amitriptyline, imipramine, clomipramine, and trimipramine were 2.60, 16.8, 14.4, and 11.2 microM in UGT2B10 and 448, 262, 112, and 258 microM in UGT1A4, respectively.	Imipramine	98-108	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	183-190	
20133892-3	2010	The kinetics of amitriptyline and imipramine glucuronidation in human liver microsomes exhibited a biphasic character, where the high- and low-affinity components were in good agreement with our results in expressed UGT2B10 and UGT1A4, respectively.	Imipramine	34-44	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	216-223	
20133892-5	2010	The in vitro clearances (CL(int) or CL(max)) were comparable between UGT2B10 and UGT1A4 for glucuronidation of imipramine, clomipramine, and trimipramine, whereas CL(int) of amitriptyline glucuronidation by UGT2B10 was more than 10-fold higher than that by UGT1A4.	Imipramine	111-121	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	69-76