PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20665703-7 2011 The combination of ZD6474 with paclitaxel versus either agent alone also more potently down-regulated the antiapoptotic bcl-2 protein, up-regulated pro-apoptotic signaling events involving expression of bax, activation of caspase-3 and caspase-7 proteins, and induced poly(ADP-ribose) polymerase resulting in apoptosis. vandetanib 19-25 BCL2 associated X, apoptosis regulator Homo sapiens 203-206 24138843-10 2013 The combination of ZD6474 with UV-B vs. either agent alone also more potently down-regulated the anti-apoptotic bcl-2 protein, up-regulated pro-apoptotic signaling events involving expression of bax, activation of caspase-3 and caspase-7 proteins, and induced poly (ADP-ribose) polymerase resulting in apoptosis. vandetanib 19-25 BCL2 associated X, apoptosis regulator Homo sapiens 195-198 20139705-7 2010 ZD6474 also downregulated anti-apoptotic markers including Bcl-2, upregulated pro-apoptotic signaling events involving expression of bax, activation of caspase-3, and induction of poly (ADP-ribose) polymerase during apoptosis. vandetanib 0-6 BCL2 associated X, apoptosis regulator Homo sapiens 133-136