PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12351409-8 2002 CDDO-induced apoptosis of CLL B cells was blocked by cytokine response modifier A (CrmA), a suppressor of caspase-8, but not by X-linked inhibitor of apoptosis protein-baculovirus IAP repeat-3 (XIAP-BIR3), a fragment of XIAP, which selectively inhibits caspase-9. 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid 0-4 caspase 9 Homo sapiens 253-262 14990979-5 2004 The pattern of CDDO-induced caspase processing, defined by use of a caspase inhibitor, strongly suggested that caspase-9 was the apical caspase. 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid 15-19 caspase 9 Homo sapiens 111-120 14990979-8 2004 Thus, in both cell types, CDDO induced apoptosis primarily by the intrinsic pathway with caspase-9 as the apical caspase. 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid 26-30 caspase 9 Homo sapiens 89-98