PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27257011-0	2016	Shikonin Induces Apoptotic Cell Death via Regulation of p53 and Nrf2 in AGS Human Stomach Carcinoma Cells.	shikonin	0-8	tumor protein p53	Homo sapiens	56-59	
31452796-9	2019	In summary, shikonin can sensitize esophageal cancer cells to paclitaxel-treatment by promoting cell mitotic arrest and reinforcing the susceptibility of esophageal cancer cells to apoptosis induced by paclitaxel, which is potentially associated with altered levels of Bcl-2 and p53.	shikonin	12-20	tumor protein p53	Homo sapiens	279-282	
22446899-8	2012	RESULTS: Shikonin induces the generation of ROS, depletion of GSH, disruption of mitochondrial transmembrane potential, upregulation of p53, and cleavage of PARP [poly(ADP-ribose) polymerase] in U87MG glioma cells.	shikonin	9-17	tumor protein p53	Homo sapiens	136-139	
15899123-10	2005	CONCLUSION: Shikonin induces HeLa cell apoptosis through the ERK, p53 and caspase pathways.	shikonin	12-20	tumor protein p53	Homo sapiens	66-69	
34867391-0	2021	Up-Regulation of p53/miR-628-3p Pathway, a Novel Mechanism of Shikonin on Inhibiting Proliferation and Inducing Apoptosis of A549 and PC-9 Non-Small Cell Lung Cancer Cell Lines.	shikonin	62-70	tumor protein p53	Homo sapiens	17-20	
34374263-7	2021	Results: In vitro experiments, shikonin could inhibit the proliferation of SMMC-7721 cells and induce their apoptosis(P<0.01), up-regulate the expression of p53 gene, down-regulate the phosphorylation levels of AKT and PI3K protein.	shikonin	31-39	tumor protein p53	Homo sapiens	157-160	
25737737-0	2015	Shikonin Induces Apoptosis, Necrosis, and Premature Senescence of Human A549 Lung Cancer Cells through Upregulation of p53 Expression.	shikonin	0-8	tumor protein p53	Homo sapiens	119-122	
15453709-0	2004	Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells.	shikonin	26-34	tumor protein p53	Homo sapiens	97-100	
15453709-6	2004	Here, we found that shikonin-induced apoptotic cell death was accompanied by upregulation of p27, p53, and Bad and down-regulation of Bcl-2 and Bcl-X(L), while shikonin had little effect on the levels of Bax protein.	shikonin	20-28	tumor protein p53	Homo sapiens	98-101