PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32705271-0	2020	Shikonin blocks human lung adenocarcinoma cell migration and invasion in the inflammatory microenvironment via the IL-6/STAT3 signaling pathway.	shikonin	0-8	interleukin 6	Homo sapiens	115-119	
35328817-12	2022	Our results demonstrate for the first time that shikonin derivatives have extensive effects on the inflammatory processes, MAPKs, and IL6/STAT3 downstream regulation in healthy and OA chondrocytes.	shikonin	48-56	interleukin 6	Homo sapiens	134-137	
32705271-5	2020	In addition, we found that interleukin-6 (IL-6), which is expressed in THP-1-CM, promoted the EMT of lung adenocarcinoma cells, and shikonin markedly inhibited IL-6-induced EMT and cell motility.	shikonin	132-140	interleukin 6	Homo sapiens	160-164	
32705271-6	2020	Moreover, shikonin inhibited IL-6-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3), prevented phosphorylated STAT3 (p-STAT3) translocation into the nucleus, and suppressed p-STAT3 transactivation activity.	shikonin	10-18	interleukin 6	Homo sapiens	29-33	
32705271-9	2020	Together, these results suggest that shikonin suppresses the migration and invasion of human lung adenocarcinoma cells in an inflammatory microenvironment involving the IL-6/STAT3 signaling pathway.	shikonin	37-45	interleukin 6	Homo sapiens	169-173	
27072015-6	2016	Shikonin prevented IL-1beta- or tumor necrosis factor (TNF)-alpha-mediated IL-6, IL-8, and CCL20 production in HPDLC.	shikonin	0-8	interleukin 6	Homo sapiens	75-79	
29642242-9	2018	Shikonin attenuated the expression of cyclooxygenase-2 and inducible nitric oxide synthase, and myeloperoxidase activity, and inhibited the production of interleukin-6 and activation of nuclear factor-kappaB.	shikonin	0-8	interleukin 6	Homo sapiens	154-167	
32802141-8	2020	Shikonin significantly inhibited Der p 2-induced expression of interleukin (IL)-6, IL-9, and IL-17A; monocyte chemoattractant protein (MCP)-1; macrophage inflammatory protein (MIP)-1alpha; MIP-1beta; and Chemokine (C-C motif) ligand 5 (RANTES).	shikonin	0-8	interleukin 6	Homo sapiens	63-81