PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25201287-2 2015 This phenomenon, which may impair insulin secretion, has been suggested to be a reason for the adverse effects on glucose metabolism associated with thiazide diuretic treatment of hypertension. Thiazides 149-157 insulin Homo sapiens 34-41 23837919-3 2013 Previous randomized clinical trials have linked thiazide diuretic treatment to insulin resistance, metabolic syndrome, and increased incidence of type 2 diabetes. Thiazides 48-56 insulin Homo sapiens 79-86 19901136-3 2009 RESULTS: The results of thiazide-based therapy in young and old are consistently positive despite concerns about some metabolic changes, eg, insulin resistance or hypokalemia, that may occur. Thiazides 24-32 insulin Homo sapiens 141-148 23424237-0 2013 Effects on insulin action of adding low-dose thiazide to angiotensin-converting enzyme inhibitor in essential hypertension. Thiazides 45-53 insulin Homo sapiens 11-18 20964809-2 2010 Acute cholecystitis is a well-known complication during treatment with thiazide, and these drugs are also reported to be followed by pronounced insulin resistance. Thiazides 71-79 insulin Homo sapiens 144-151 8941469-7 1996 Among women, fasting insulin was significantly and positively associated with bone density of the radius and spine (P < 0.05), independent of age, BMI, waist-hip ratio, postmenopausal estrogen use, age at menopause, thiazide use, family history of diabetes, current cigarette smoking, and exercise. Thiazides 219-227 insulin Homo sapiens 21-28 18445178-0 2008 Comparison of effects of combined ACE inhibitor and low-dose thiazide diuretic with ACE inhibitor alone on insulin action in patients with hypertension and Type 2 diabetes: a double-blind crossover study. Thiazides 61-69 insulin Homo sapiens 107-114 18445178-1 2008 AIMS: To establish the safety in terms of insulin sensitivity of a low dose thiazide/ACE inhibitor combination. Thiazides 76-84 insulin Homo sapiens 42-49 10391396-0 1999 Comparison of effects of captopril used either alone or in combination with a thiazide diuretic on insulin action in hypertensive Type 2 diabetic patients: a double-blind crossover study. Thiazides 78-86 insulin Homo sapiens 99-106 10391396-2 1999 It has also been suggested that angiotensin converting enzyme (ACE) inhibitors reduce insulin resistance and that, if used together with thiazide diuretics, the adverse effects of thiazides on insulin sensitivity may be eliminated. Thiazides 180-189 insulin Homo sapiens 193-200 9533423-0 1998 Effects of combination therapy with an angiotensin converting enzyme inhibitor and thiazide diuretic on insulin action in essential hypertension. Thiazides 83-91 insulin Homo sapiens 104-111 9533423-16 1998 It cannot be assumed that combined preparations with angiotensin converting enzyme inhibitors will ameliorate adverse effects of high doses of thiazide diuretics on insulin action. Thiazides 143-151 insulin Homo sapiens 165-172 19546456-8 2009 In contrast, patients who received thiazides or who used up to 12 medications (v. none) were less likely to have insulin therapy initiated. Thiazides 35-44 insulin Homo sapiens 113-120 8551491-5 1995 A decreased pretreatment insulin sensitivity was related to a poor DBP treatment response in the thiazide-treated group only (r = -0.33, P < 0.05). Thiazides 97-105 insulin Homo sapiens 25-32 8551491-3 1995 Insulin sensitivity was evaluated by the hyperinsulinaemic euglycaemic clamp technique before initiation of treatment with beta-adrenergic blockers (n = 181), thiazide diuretics (n = 60), ACE inhibitors (n = 73), non-dihydropyridine calcium antagonists (n = 38), dihydropyridine calcium antagonists (n = 26) or alpha-1 antagonists (n = 39) over periods of 3-6 months in hypertensive patients. Thiazides 159-167 insulin Homo sapiens 0-7 9036679-7 1996 The adverse effects of thiazides on insulin action, glycemia and lipid profile are dose dependent and can be minimized by using low doses. Thiazides 23-32 insulin Homo sapiens 36-43 7556989-0 1995 A comparison of the effects of low- and conventional-dose thiazide diuretic on insulin action in hypertensive patients with NIDDM. Thiazides 58-66 insulin Homo sapiens 79-86 8206564-1 1994 We investigated serum glucose and insulin levels resulting from thiazide or thiazide-like diuretic administration and determined whether they were associated with serum or intracellular potassium or magnesium values. Thiazides 64-72 insulin Homo sapiens 34-41 7818648-0 1994 Effects of low dose versus conventional dose thiazide diuretic on insulin action in essential hypertension. Thiazides 45-53 insulin Homo sapiens 66-73 8206564-1 1994 We investigated serum glucose and insulin levels resulting from thiazide or thiazide-like diuretic administration and determined whether they were associated with serum or intracellular potassium or magnesium values. Thiazides 76-84 insulin Homo sapiens 34-41 8175960-5 1994 Compared with nonusers, women taking thiazides had significantly lower high density lipoprotein cholesterol levels and significantly higher fasting triglyceride, glucose, and insulin levels. Thiazides 37-46 insulin Homo sapiens 175-182 8175960-6 1994 Concomitant use of thiazide and estrogen yielded lipid profiles and fasting glucose and insulin levels similar to those of subjects receiving estrogen alone, i.e. elevated high density lipoproteins, decreased low density lipoproteins, and lower levels of fasting glucose and insulin compared with those in nonusers. Thiazides 19-27 insulin Homo sapiens 88-95 8175960-6 1994 Concomitant use of thiazide and estrogen yielded lipid profiles and fasting glucose and insulin levels similar to those of subjects receiving estrogen alone, i.e. elevated high density lipoproteins, decreased low density lipoproteins, and lower levels of fasting glucose and insulin compared with those in nonusers. Thiazides 19-27 insulin Homo sapiens 275-282 8175960-7 1994 However, thiazide-associated postchallenge glucose and insulin elevations were not modified by estrogen. Thiazides 9-17 insulin Homo sapiens 55-62 1593308-6 1992 An analysis of available data from controlled studies has shown that the use of thiazides is correlated with a decrease in insulin sensitivity. Thiazides 80-89 insulin Homo sapiens 123-130 1418829-2 1992 Thiazide treated patients had lower arterial blood pressure, plasma ion levels, erythrocyte magnesium and potassium content but higher fasting plasma insulin (66 +/- 7 v 87 +/- 8 pmol/L P < .02), triglycerides (1.88 +/- 0.24 v 2.34 +/- 0.44 mmol/L P < .05), free fatty acids (0.68 +/- 0.11 v 0.81 +/- 0.18 mmol/L P < .05). Thiazides 0-8 insulin Homo sapiens 150-157 1438100-12 1992 Thiazide diuretics and beta-blockers aggravate insulin resistance while angiotensin converting-enzyme inhibitors correct this condition. Thiazides 0-8 insulin Homo sapiens 47-54 1735589-2 1992 Increases in plasma insulin and glucose levels have been observed in thiazide-treated hypertensive patients and have been attributed to a diminished insulin sensitivity induced by diuretic therapy. Thiazides 69-77 insulin Homo sapiens 20-27 1735589-2 1992 Increases in plasma insulin and glucose levels have been observed in thiazide-treated hypertensive patients and have been attributed to a diminished insulin sensitivity induced by diuretic therapy. Thiazides 69-77 insulin Homo sapiens 149-156 1877473-9 1991 Commonly used antihypertensive agents, such as thiazide, thiazide-like diuretics, and beta-blockers, are associated with glucose intolerance and increased insulin resistance. Thiazides 47-55 insulin Homo sapiens 155-162 1748056-2 1991 These trials, which included assessment of insulin sensitivity by the euglycemic insulin clamp, showed that beta-adrenergic blockade and thiazide diuretic treatment (hydrochlorothiazide) increase insulin resistance and basal plasma insulin, whereas Ca(2+)-channel antagonists (verapamil and diltiazem), with the exception of the negative effect of nifedipine, are metabolically neutral. Thiazides 137-145 insulin Homo sapiens 43-50 1748056-2 1991 These trials, which included assessment of insulin sensitivity by the euglycemic insulin clamp, showed that beta-adrenergic blockade and thiazide diuretic treatment (hydrochlorothiazide) increase insulin resistance and basal plasma insulin, whereas Ca(2+)-channel antagonists (verapamil and diltiazem), with the exception of the negative effect of nifedipine, are metabolically neutral. Thiazides 137-145 insulin Homo sapiens 81-88 1748056-2 1991 These trials, which included assessment of insulin sensitivity by the euglycemic insulin clamp, showed that beta-adrenergic blockade and thiazide diuretic treatment (hydrochlorothiazide) increase insulin resistance and basal plasma insulin, whereas Ca(2+)-channel antagonists (verapamil and diltiazem), with the exception of the negative effect of nifedipine, are metabolically neutral. Thiazides 137-145 insulin Homo sapiens 81-88 1748056-2 1991 These trials, which included assessment of insulin sensitivity by the euglycemic insulin clamp, showed that beta-adrenergic blockade and thiazide diuretic treatment (hydrochlorothiazide) increase insulin resistance and basal plasma insulin, whereas Ca(2+)-channel antagonists (verapamil and diltiazem), with the exception of the negative effect of nifedipine, are metabolically neutral. Thiazides 137-145 insulin Homo sapiens 81-88 1877473-9 1991 Commonly used antihypertensive agents, such as thiazide, thiazide-like diuretics, and beta-blockers, are associated with glucose intolerance and increased insulin resistance. Thiazides 57-65 insulin Homo sapiens 155-162 1867224-18 1991 Thiazides and some beta blockers may further impair tissue insulin sensitivity and often cause blood lipoprotein abnormalities. Thiazides 0-9 insulin Homo sapiens 59-66 2043227-5 1991 Present experience suggests that thiazide-induced impairment of glucose tolerance is due to both reduced glucose-stimulated insulin release and increased peripheral resistance to the action of insulin. Thiazides 33-41 insulin Homo sapiens 124-131 2041930-2 1991 The mean value of insulin resistance was higher in a hypertensive group than among the normotensives, independent of body mass index, physical activity, smoking sex, age, and thiazide treatment. Thiazides 175-183 insulin Homo sapiens 18-25 2043227-5 1991 Present experience suggests that thiazide-induced impairment of glucose tolerance is due to both reduced glucose-stimulated insulin release and increased peripheral resistance to the action of insulin. Thiazides 33-41 insulin Homo sapiens 193-200 3289352-7 1988 In addition, glucose tolerance may worsen with thiazide therapy, perhaps because newer evidence suggests that insulin resistance is common in essential hypertension. Thiazides 47-55 insulin Homo sapiens 110-117 1694928-7 1990 Recently, careful studies have shown that both thiazide diuretic and beta-adrenoreceptor blockers worsen insulin sensitivity, whereas angiotensin converting enzyme inhibitors (captopril) and peripheral alpha 1-blockers (prazosin) improve it and also favorably affect the levels of other atherogenic risk factors. Thiazides 47-55 insulin Homo sapiens 105-112 3542455-0 1986 Insulin action in insulin-dependent diabetics after short-term thiazide therapy. Thiazides 63-71 insulin Homo sapiens 0-7 3542455-1 1986 The influence of short-term thiazide treatment on peripheral tissue and liver sensitivity to insulin in insulin-dependent diabetes mellitus was determined by the euglycemic insulin clamp technique. Thiazides 28-36 insulin Homo sapiens 93-100 2867040-3 1985 Indirect evidence suggests that changes in the serum potassium are at least contributory, although the principal mechanism of thiazide-induced hyperglycemia is probably a reduction in the insulin response to glucose. Thiazides 126-134 insulin Homo sapiens 188-195 515777-2 1979 On subsequent follow-up one patient is taking no insulin and has been maintained on hydrochlorothiazide; the other patient required insulin on two occasions when challenged with a propranolol-thiazide combination, but not when the thiazide was discontinued or replaced with furosemide. Thiazides 192-200 insulin Homo sapiens 132-139 4868989-0 1968 Effect of thiazides upon insulin secretion in vitro. Thiazides 10-19 insulin Homo sapiens 25-32