PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23585646-5 2013 DATA SYNTHESIS: The antihypertensive combination tablet azilsartan medoxomil/chlorthalidone is the first to combine an inhibitor of the renin-angiotensin-aldosterone system with chlorthalidone, a thiazide-type diuretic. Thiazides 196-204 renin Homo sapiens 136-141 26418513-8 2016 The addition of a thiazide diuretic to an inhibitor of the renin-angiotensin system significantly increased the prevalence of ED. Thiazides 18-26 renin Homo sapiens 59-64 27122683-1 2013 BACKGROUND: The baseline status of renin-angiotensin-aldosterone system (RAAS) might modify the blood pressure (BP) lowering effects of thiazide diuretics. Thiazides 136-144 renin Homo sapiens 35-40 27122683-2 2013 This study aimed to determine if baseline RAAS indicated by serum aldosterone-to-renin ratio (ARR) could be associated with the add-on effects of thiazide on BP lowering in patients with other concomitant antihypertensive medication. Thiazides 146-154 renin Homo sapiens 81-86 20725057-0 2010 Plasma renin activity predicts blood pressure responses to beta-blocker and thiazide diuretic as monotherapy and add-on therapy for hypertension. Thiazides 76-84 renin Homo sapiens 7-12 22547363-10 2012 The addition of a thiazide type diuretic to a blocker of the renin-angiotensin system is also sensible and popular with numerous available fixed combinations. Thiazides 18-26 renin Homo sapiens 61-66 19696778-9 2009 Plasma levels of renin, angiotensin II and aldosterone were also increased with the thiazide period, whereas high-sensitivity C-reactive protein and oxidized low-density lipoprotein were decreased with azelnidipine. Thiazides 84-92 renin Homo sapiens 17-22 18184024-4 2008 Knowledge of pathophysiological changes in older subjects (decreased elastic artery compliance, reduced plasma renin activity, increased salt sensitivity) and evidence from epidemiological surveys and randomized controlled trials give clear clues that thiazide(-like) diuretics and long-acting dihydropyridine calcium channel antagonists are the drugs of choice in the treatment of ISH. Thiazides 252-260 renin Homo sapiens 111-116 18250276-0 2008 Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio". Thiazides 86-94 renin Homo sapiens 152-157 18250276-0 2008 Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio". Thiazides 86-94 renin Homo sapiens 196-201 17606839-4 2007 Our primary hypothesis was that in low-renin patients with normal plasma K+ and aldosterone, a thiazide diuretic, bendroflumethiazide, would be as effective as spironolactone in overcoming the Na+ retention and lowering blood pressure. Thiazides 95-103 renin Homo sapiens 39-44 16403686-7 2005 During blockade of the renin-angiotensin system low doses of thiazides generally suffice, allowing the prevention of undesirable metabolic effects. Thiazides 61-70 renin Homo sapiens 23-28 15690192-1 2005 Low-renin hypertension responsive to amiloride-thiazide therapy in a 4-year-old Afro-Haitian girl suggested Liddle syndrome. Thiazides 47-55 renin Homo sapiens 4-9 3159197-5 1985 These findings suggest that systemic PGs are mainly involved in the control of renin during standing and angiotensin-converting enzyme (ACE) inhibition, while mainly renal PGs play a role in the control of renin during chronic thiazide-like diuretic administration. Thiazides 227-235 renin Homo sapiens 206-211 2565158-0 1989 Bevantolol attenuates thiazide stimulated renin secretion and catecholamine release in diuretic resistant hypertensives. Thiazides 22-30 renin Homo sapiens 42-47 2565158-6 1989 Inhibition of thiazide stimulated renin release by bevantolol may contribute to the antihypertensive effect of the combined therapy. Thiazides 14-22 renin Homo sapiens 34-39 3883613-0 1985 [Urinary excretion of prostaglandins and changes in plasma renin levels in patients with rheumatoid arthritis associated with cardiac decompensation treated with thiazides]. Thiazides 162-171 renin Homo sapiens 59-64 6428366-9 1984 We have observed that therapy with a thiazide diuretic results in a reduction of serum potassium and a greater increase in renin activity than therapy with the potassium-retaining diuretic, spironolactone, despite comparable natriuretic responses with both drugs. Thiazides 37-45 renin Homo sapiens 123-128 6428366-11 1984 The greater effect of thiazides on renin activity and the greater effect of spironolactone on aldosterone production may be related to the thiazide induced reduction of serum potassium and the spironolactone induced increases of serum potassium. Thiazides 22-31 renin Homo sapiens 35-40 6695763-5 1984 The addition of a thiazide diuretic in persons who did not achieve goal blood pressure on prazosin alone was generally successful in reducing blood pressure to desired levels, and increased both plasma renin activity and aldosterone concentrations. Thiazides 18-26 renin Homo sapiens 202-207 1362543-5 1992 Thus, the activation of the renin-angiotensin-aldosterone cascade appears to be partially responsible for the flat dose-blood pressure response curve of thiazides in hypertensive patients. Thiazides 153-162 renin Homo sapiens 28-33 6394759-0 1984 The renal excretion of prostaglandins and changes in plasma renin during treatment with either sulindac or naproxen in patients with rheumatoid arthritis and thiazide treated heart failure. Thiazides 158-166 renin Homo sapiens 60-65 7018804-0 1981 Captopril combined with thiazide lowers renin substrate concentration: implications for methodology in renin assays. Thiazides 24-32 renin Homo sapiens 40-45 7018804-0 1981 Captopril combined with thiazide lowers renin substrate concentration: implications for methodology in renin assays. Thiazides 24-32 renin Homo sapiens 103-108 469152-5 1979 The fluctuation of plasma renin activity in response to an excess of sodium chloride or to thiazide treatment was reduced progressively with age. Thiazides 91-99 renin Homo sapiens 26-31 6992515-0 1980 Body fluid volumes and the response of renin and aldosterone to short- and long-term thiazide therapy of essential hypertension. Thiazides 85-93 renin Homo sapiens 39-44 498696-0 1979 Effects of metoprolol on blood pressure and plasma renin activity in thiazide-resistant hypertensive patients. Thiazides 69-77 renin Homo sapiens 51-56 282041-9 1978 Stimulation with oral thiazide over 5 days induced a seven-fold rise of active renin, with a doubling of inactive renin. Thiazides 22-30 renin Homo sapiens 79-84 282041-9 1978 Stimulation with oral thiazide over 5 days induced a seven-fold rise of active renin, with a doubling of inactive renin. Thiazides 22-30 renin Homo sapiens 114-119 282041-10 1978 Thiazide treatment for 3 months led to a four-fold rise of active renin and a three-fold rise of inactive renin. Thiazides 0-8 renin Homo sapiens 66-71 282041-10 1978 Thiazide treatment for 3 months led to a four-fold rise of active renin and a three-fold rise of inactive renin. Thiazides 0-8 renin Homo sapiens 106-111 328540-3 1977 However, significant biochemical changes in the renin-aldosterone system were found in patients receiving the spironolactone/thiazide combination therapy. Thiazides 125-133 renin Homo sapiens 48-53 328540-4 1977 A significant increase in plasma renin activity and a significantly greater increase in aldosterone excretion were found in the spironolactone/thiazide group compared to the furosemide group. Thiazides 143-151 renin Homo sapiens 33-38 4294498-0 1968 Renin-angiotensin-aldosterone system during chronic thiazide therapy of benign hypertension. Thiazides 52-60 renin Homo sapiens 0-5 33150452-11 2021 Both renin and aldosterone were higher in thiazide users. Thiazides 42-50 renin Homo sapiens 5-10 802630-0 1975 Antihypertensive drugs in combination: Effects of methyldopa on thiazide-induced changes in renal hemodynamics and plasma renin activity. Thiazides 64-72 renin Homo sapiens 122-127 802630-1 1975 The rise in plasma renin activity (PRA) that accompanies thiazide diuretic therapy of hypertension may interfere with therapeutic effectiveness and contribute to hypokalemia. Thiazides 57-65 renin Homo sapiens 19-24 4472877-0 1974 [Fall of blood pressure and fluctuation of plasma renin activities caused by thiazides]. Thiazides 77-86 renin Homo sapiens 50-55