PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30471562-0	2019	Vitamin E delta-tocotrienol inhibits TNF-alpha-stimulated NF-kappaB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides.	tocotrienol, delta	10-27	TNF alpha induced protein 3	Homo sapiens	117-120	
30471562-7	2019	In pursuit of the cause for A20 induction, we found that deltaTE treatment caused rapid and persistent elevation of dihydroceramides, while decreased ceramides initially but increased ceramides during prolonged treatment.	tocotrienol, delta	57-64	TNF alpha induced protein 3	Homo sapiens	28-31	
30471562-9	2019	Importantly, deltaTE"s induction of A20 and inhibition of NF-kappaB activation were partially counteracted by myriocin, a potent inhibitor of de novo synthesis of sphingolipids, indicating a critical role of sphingolipid modulation in deltaTE-mediated effects.	tocotrienol, delta	13-20	TNF alpha induced protein 3	Homo sapiens	36-39	
30471562-9	2019	Importantly, deltaTE"s induction of A20 and inhibition of NF-kappaB activation were partially counteracted by myriocin, a potent inhibitor of de novo synthesis of sphingolipids, indicating a critical role of sphingolipid modulation in deltaTE-mediated effects.	tocotrienol, delta	235-242	TNF alpha induced protein 3	Homo sapiens	36-39	
30471562-10	2019	Since dihydroceramide has been shown to induce A20 and inhibit NF-kappaB in RAW cells, we conclude that that deltaTE inhibits NF-kappaB activation by enhancing its negative regulator A20 as a result of modulating sphingolipids especially elevation of dihydroceramides.	tocotrienol, delta	109-116	TNF alpha induced protein 3	Homo sapiens	47-50	
30471562-10	2019	Since dihydroceramide has been shown to induce A20 and inhibit NF-kappaB in RAW cells, we conclude that that deltaTE inhibits NF-kappaB activation by enhancing its negative regulator A20 as a result of modulating sphingolipids especially elevation of dihydroceramides.	tocotrienol, delta	109-116	TNF alpha induced protein 3	Homo sapiens	183-186