PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23393547-7 2013 Furthermore, delta-tocotrienol induced p27(Kip1) mRNA expression but not its protein degradation. tocotrienol, delta 13-30 cyclin dependent kinase inhibitor 1B Homo sapiens 43-47 23393547-0 2013 Vitamin E delta-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. tocotrienol, delta 10-27 cyclin dependent kinase inhibitor 1B Homo sapiens 40-44 23393547-3 2013 We also showed that delta-tocotrienol-induced growth inhibition occurred concomitantly with G(1) cell-cycle arrest and increased p27(Kip1) nuclear accumulation. tocotrienol, delta 20-37 cyclin dependent kinase inhibitor 1B Homo sapiens 133-137 23393547-5 2013 Furthermore, delta-tocotrienol inactivated RAF-MEK-ERK signaling, a pathway known to suppress p27(Kip1) expression. tocotrienol, delta 13-30 cyclin dependent kinase inhibitor 1B Homo sapiens 98-102 23393547-8 2013 p27(Kip1) gene promoter activity was induced by delta-tocotrienol through the promoter"s E2F-1 binding site, and this activity was attenuated by E2F-1 depletion using E2F-1 small interfering RNA. tocotrienol, delta 48-65 cyclin dependent kinase inhibitor 1B Homo sapiens 4-8 23393547-10 2013 Our findings reveal a new mechanism, dependent on p27(Kip1) induction, by which delta-tocotrienol can inhibit proliferation in PDCA cells, providing a new rationale for p27(Kip1) as a biomarker for delta-tocotrienol efficacy in pancreatic cancer prevention and therapy. tocotrienol, delta 80-97 cyclin dependent kinase inhibitor 1B Homo sapiens 54-58 23393547-10 2013 Our findings reveal a new mechanism, dependent on p27(Kip1) induction, by which delta-tocotrienol can inhibit proliferation in PDCA cells, providing a new rationale for p27(Kip1) as a biomarker for delta-tocotrienol efficacy in pancreatic cancer prevention and therapy. tocotrienol, delta 80-97 cyclin dependent kinase inhibitor 1B Homo sapiens 173-177 23393547-10 2013 Our findings reveal a new mechanism, dependent on p27(Kip1) induction, by which delta-tocotrienol can inhibit proliferation in PDCA cells, providing a new rationale for p27(Kip1) as a biomarker for delta-tocotrienol efficacy in pancreatic cancer prevention and therapy. tocotrienol, delta 198-215 cyclin dependent kinase inhibitor 1B Homo sapiens 173-177