PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20014870-1	2009	In the framework of the design and development of TGR5 agonists, we reported that the introduction of a C(23)(S)-methyl group in the side chain of bile acids such as chenodeoxycholic acid (CDCA) and 6-ethylchenodeoxycholic acid (6-ECDCA, INT-747) affords selectivity for TGR5.	obeticholic acid	199-227	G protein-coupled bile acid receptor 1	Homo sapiens	50-54	
25200104-4	2014	AREAS COVERED: The semisynthetic bile acid derivative 6-ethyl chenodeoxycholic acid (6-ECDCA, INT-747 later christened obeticholic acid) is a dual FXR/GP-BAR1 ligand that attenuates bile flow impairment in cholestasis induced by 17beta-estradiol; a model of pregnancy-induced cholestasis.	obeticholic acid	54-83	G protein-coupled bile acid receptor 1	Homo sapiens	151-158	
25200104-4	2014	AREAS COVERED: The semisynthetic bile acid derivative 6-ethyl chenodeoxycholic acid (6-ECDCA, INT-747 later christened obeticholic acid) is a dual FXR/GP-BAR1 ligand that attenuates bile flow impairment in cholestasis induced by 17beta-estradiol; a model of pregnancy-induced cholestasis.	obeticholic acid	85-92	G protein-coupled bile acid receptor 1	Homo sapiens	151-158	
25200104-4	2014	AREAS COVERED: The semisynthetic bile acid derivative 6-ethyl chenodeoxycholic acid (6-ECDCA, INT-747 later christened obeticholic acid) is a dual FXR/GP-BAR1 ligand that attenuates bile flow impairment in cholestasis induced by 17beta-estradiol; a model of pregnancy-induced cholestasis.	obeticholic acid	119-135	G protein-coupled bile acid receptor 1	Homo sapiens	151-158	
20014870-1	2009	In the framework of the design and development of TGR5 agonists, we reported that the introduction of a C(23)(S)-methyl group in the side chain of bile acids such as chenodeoxycholic acid (CDCA) and 6-ethylchenodeoxycholic acid (6-ECDCA, INT-747) affords selectivity for TGR5.	obeticholic acid	199-227	G protein-coupled bile acid receptor 1	Homo sapiens	271-275	
20014870-1	2009	In the framework of the design and development of TGR5 agonists, we reported that the introduction of a C(23)(S)-methyl group in the side chain of bile acids such as chenodeoxycholic acid (CDCA) and 6-ethylchenodeoxycholic acid (6-ECDCA, INT-747) affords selectivity for TGR5.	obeticholic acid	229-236	G protein-coupled bile acid receptor 1	Homo sapiens	50-54	
27409173-6	2016	Exposure of MKN45 cells to GPBAR1 ligands, TLCA, oleanolic acid or 6-ECDCA (a dual FXR and GPBAR1 ligand) increased the expression of genes associated with EMT including KDKN2A, HRAS, IGB3, MMP10 and MMP13 and downregulated the expression of CD44 and FAT1 (P<0.01 versus control cells).	obeticholic acid	67-74	G protein-coupled bile acid receptor 1	Homo sapiens	27-33	
27409173-6	2016	Exposure of MKN45 cells to GPBAR1 ligands, TLCA, oleanolic acid or 6-ECDCA (a dual FXR and GPBAR1 ligand) increased the expression of genes associated with EMT including KDKN2A, HRAS, IGB3, MMP10 and MMP13 and downregulated the expression of CD44 and FAT1 (P<0.01 versus control cells).	obeticholic acid	67-74	G protein-coupled bile acid receptor 1	Homo sapiens	91-97