PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25488359-3	2015	Nobiletin dose dependently reduced ET plus SCF-stimulated tyrosinase activity without causing cytotoxicity.	nobiletin	0-9	tyrosinase	Homo sapiens	58-68	
25488359-4	2015	Nobiletin reduced cAMP-response element-binding protein (CREB) phosphorylation and microphthalmia-associated transcription factor (MITF) expression, which is a key transcription factor for tyrosinase expression in pigmentation induced by ET plus SCF stimulation.	nobiletin	0-9	tyrosinase	Homo sapiens	189-199	
25488359-6	2015	Furthermore, nobiletin inhibited ET plus SCF-triggered production of melanin and expression of MITF/tyrosinase in a three-dimensional human epidermal model.	nobiletin	13-22	tyrosinase	Homo sapiens	100-110	
25488359-8	2015	Nobiletin contributes to hypopigmentation by downregulating MITF and tyrosinase expression through reduced Raf-1 phosphorylation.	nobiletin	0-9	tyrosinase	Homo sapiens	69-79	
12081153-0	2002	Nobiletin as a tyrosinase inhibitor from the peel of Citrus fruit.	nobiletin	0-9	tyrosinase	Homo sapiens	15-25	
12081153-1	2002	A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3",4",5,6,7,8-hexamethoxyflavone (nobiletin) by comparison with reported spectral data.	nobiletin	118-150	tyrosinase	Homo sapiens	2-12	
12081153-1	2002	A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3",4",5,6,7,8-hexamethoxyflavone (nobiletin) by comparison with reported spectral data.	nobiletin	152-161	tyrosinase	Homo sapiens	2-12