PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29501626-5 2018 Importantly, NOB was found to be effective at amplifying glucose uptake via stimulating IRS-1/AKT signaling pathway, as well as blunting palmitate-induced lipogenesis in HepG2 cells via modulating AMPK-Sirt1 signaling pathway and key enzymes of de novo lipogenesis in a Bmal1-dependent manner. nobiletin 13-16 AKT serine/threonine kinase 1 Homo sapiens 94-97 29635125-0 2018 Nobiletin (NOB) suppresses autophagic degradation via over-expressing AKT pathway and enhances apoptosis in multidrug-resistant SKOV3/TAX ovarian cancer cells. nobiletin 0-9 AKT serine/threonine kinase 1 Homo sapiens 70-73 29635125-0 2018 Nobiletin (NOB) suppresses autophagic degradation via over-expressing AKT pathway and enhances apoptosis in multidrug-resistant SKOV3/TAX ovarian cancer cells. nobiletin 11-14 AKT serine/threonine kinase 1 Homo sapiens 70-73 26878777-5 2016 Nobiletin inhibited the phosphorylation of phospholipase PLCgamma2, protein kinase PKC, Akt and mitogen-activated protein kinase MAPKs in collagen-activated human platelets and markedly reduced intracellular calcium mobilization and hydroxyl radical (OH( )) formation. nobiletin 0-9 AKT serine/threonine kinase 1 Homo sapiens 88-91 29687528-7 2018 Meanwhile, LY294002, an inhibitor of PI3K/Akt, abolished the protective effect of nobiletin against H2 O2 -induced decreased cell viability and increased caspase-3/7 activity in ARPE-19 cells. nobiletin 82-91 AKT serine/threonine kinase 1 Homo sapiens 42-45 28339056-0 2017 Nobiletin inhibits invasion via inhibiting AKT/GSK3beta/beta-catenin signaling pathway in Slug-expressing glioma cells. nobiletin 0-9 AKT serine/threonine kinase 1 Homo sapiens 43-46 26560814-0 2016 Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways. nobiletin 0-9 AKT serine/threonine kinase 1 Homo sapiens 131-134 26560814-7 2016 Altogether, the present results suggest that nobiletin inhibits mitogen-activated protein kinase and Akt/protein kinase B pathways and downregulates positive regulators of the cell cycle, leading to subsequent suppression of glioma cell proliferation and migration. nobiletin 45-54 AKT serine/threonine kinase 1 Homo sapiens 101-104 26878777-9 2016 In conclusion, this study demonstrates for the first time that, in addition to being a potential agent for preventing tumor growth and inflammation, nobiletin exhibits potent antiplatelet activity, which initially inhibits the PLCgamma2/PKC cascade and hydroxyl radical formation, subsequently suppresses the activation of Akt and MAPKs and ultimately inhibits platelet activation. nobiletin 149-158 AKT serine/threonine kinase 1 Homo sapiens 323-326 26689156-6 2015 Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin. nobiletin 111-120 AKT serine/threonine kinase 1 Homo sapiens 68-71 26689156-6 2015 Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin. nobiletin 111-120 AKT serine/threonine kinase 1 Homo sapiens 195-198 26689156-6 2015 Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin. nobiletin 262-271 AKT serine/threonine kinase 1 Homo sapiens 68-71 26689156-6 2015 Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin. nobiletin 262-271 AKT serine/threonine kinase 1 Homo sapiens 195-198 25342300-0 2014 Nobiletin suppresses cell viability through AKT pathways in PC-3 and DU-145 prostate cancer cells. nobiletin 0-9 AKT serine/threonine kinase 1 Homo sapiens 44-47 25845666-0 2015 The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway. nobiletin 14-23 AKT serine/threonine kinase 1 Homo sapiens 90-93 25845666-11 2015 We observed that nobiletin inhibits secretion of the key angiogenesis mediators, Akt, HIF-1alpha, NF-kappaB and vascular epithelial growth factor (VEGF) by ovarian cancer cells. nobiletin 17-26 AKT serine/threonine kinase 1 Homo sapiens 81-84 25845666-12 2015 Transient transfection experiments showed that nobiletin inhibits production of HIF-1alpha by downregulation of Akt. nobiletin 47-56 AKT serine/threonine kinase 1 Homo sapiens 112-115 25342300-17 2014 CONCLUSION: Taken together, our results show that nobiletin suppresses cell viability through AKT pathways, with a more profound effect against the more metastatic PC-3 line. nobiletin 50-59 AKT serine/threonine kinase 1 Homo sapiens 94-97 15252145-7 2004 However, nobiletin was found to augment the phosphorylation of c-Jun NH2-terminal kinase (JNK), a downstream signal factor of the PI3K-Akt pathway, in TPA-treated HT-1080 cells. nobiletin 9-18 AKT serine/threonine kinase 1 Homo sapiens 135-138 24692711-5 2014 Nobiletin induced apoptotic cell death by reducing Bcl-xL expression, without affecting Bax levels, and inhibited the activity of AKT and downstream mTOR in MDA-MB-468 cells, but not in other cell lines. nobiletin 0-9 AKT serine/threonine kinase 1 Homo sapiens 130-133 23537747-0 2013 Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells. nobiletin 0-9 AKT serine/threonine kinase 1 Homo sapiens 54-57 20963626-0 2011 Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells. nobiletin 0-9 AKT serine/threonine kinase 1 Homo sapiens 84-87 20963626-3 2011 Data also showed nobiletin could inhibit the activation of focal adhesion kinase (FAK) and phosphoinositide-3-kinase/Akt (PI3K/Akt) involved in the downregulation of the enzyme activities, protein expressions, messenger RNA levels of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-2 (MMP-9). nobiletin 17-26 AKT serine/threonine kinase 1 Homo sapiens 117-120 20963626-4 2011 Also, our data revealed that nobiletin inhibited FAK/PI3K/Akt with concurrent reduction in the protein expressions of Ras, c-Raf, Rac-1, Cdc42, and RhoA by western blotting, whereas the protein level of RhoB increased progressively. nobiletin 29-38 AKT serine/threonine kinase 1 Homo sapiens 58-61 20963626-6 2011 Furthermore, nobiletin significantly decreased the levels of phospho-Akt and MMP-2/9 in Akt1-cDNA-transfected cells concomitantly with a marked reduction in cell invasion and migration. nobiletin 13-22 AKT serine/threonine kinase 1 Homo sapiens 69-72 20963626-6 2011 Furthermore, nobiletin significantly decreased the levels of phospho-Akt and MMP-2/9 in Akt1-cDNA-transfected cells concomitantly with a marked reduction in cell invasion and migration. nobiletin 13-22 AKT serine/threonine kinase 1 Homo sapiens 88-92 23537747-5 2013 Furthermore, nobiletin could inhibit HGF-induced the membrane localization of phosphorylated c-Met, ERK2, and Akt, but not phosphorylated JNK1/2 and p38. nobiletin 13-22 AKT serine/threonine kinase 1 Homo sapiens 110-113 23537747-6 2013 Next, nobiletin significantly decreased the levels of phospho-ERK2 and phospho-Akt in ERK2 or Akt siRNA-transfected cells concomitantly with a marked reduction on cell invasion and migration. nobiletin 6-15 AKT serine/threonine kinase 1 Homo sapiens 79-82 23537747-6 2013 Next, nobiletin significantly decreased the levels of phospho-ERK2 and phospho-Akt in ERK2 or Akt siRNA-transfected cells concomitantly with a marked reduction on cell invasion and migration. nobiletin 6-15 AKT serine/threonine kinase 1 Homo sapiens 94-97 23537747-7 2013 In conclusion, nobiletin attenuates HGF-induced HepG2 cells metastasis involving both ERK and PI3K/Akt pathways and are potentially useful as anti-metastatic agents for the treatment of hepatoma. nobiletin 15-24 AKT serine/threonine kinase 1 Homo sapiens 99-102 32129440-6 2020 Mechanistically, nobiletin significantly inhibited Akt and Erk activation in placenta, and NF-kappaB activation in VAT. nobiletin 17-26 AKT serine/threonine kinase 1 Homo sapiens 51-54 34066937-6 2021 Moreover, we revealed that nobiletin treatment could suppress the activation of the NF-kappaB, MAPKs, and Akt pathways. nobiletin 27-36 AKT serine/threonine kinase 1 Homo sapiens 106-109 30468657-0 2019 Nobiletin sensitizes colorectal cancer cells to oxaliplatin by PI3K/Akt/MTOR pathway. nobiletin 0-9 AKT serine/threonine kinase 1 Homo sapiens 68-71 31398899-0 2019 Involvement of Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and the PI3K/AKT/mTOR Pathway in Nobiletin-Induced Apoptosis of Human Bladder Cancer Cells. nobiletin 105-114 AKT serine/threonine kinase 1 Homo sapiens 85-88 31398899-7 2019 NOB-induced apoptosis was also mediated by regulating endoplasmic reticulum stress via the PERK/elF2alpha/ATF4/CHOP pathway, and downregulating the PI3K/AKT/mTOR pathway. nobiletin 0-3 AKT serine/threonine kinase 1 Homo sapiens 153-156 31354472-0 2019 Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells. nobiletin 0-9 AKT serine/threonine kinase 1 Homo sapiens 46-49 31354472-11 2019 The results further showed that application of insulin-like growth factor 1 (IGF1) was able to reverse the nobiletin-induced changes in the levels of phosphorylated AKT, phosphorylated STAT3, and phosphorylated YY1AP1, and could also reverse the antitumor effects of nobiletin. nobiletin 107-116 AKT serine/threonine kinase 1 Homo sapiens 165-168 30938722-0 2019 Inhibiting the PI3K/AKT/NF-kappaB signal pathway with nobiletin for attenuating the development of osteoarthritis: in vitro and in vivo studies. nobiletin 54-63 AKT serine/threonine kinase 1 Homo sapiens 20-23 30938722-7 2019 Furthermore, NOB dramatically suppressed the IL-1beta-stimulated phosphorylation of PI3K/Akt and activation of NF-kappaB in human OA chondrocytes. nobiletin 13-16 AKT serine/threonine kinase 1 Homo sapiens 89-92 30486290-0 2018 Nobiletin Enhances Chemosensitivity to Adriamycin through Modulation of the Akt/GSK3beta/beta-Catenin/MYCN/MRP1 Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells. nobiletin 0-9 AKT serine/threonine kinase 1 Homo sapiens 76-79 30486290-4 2018 NBT treatment decreased the expression of a neuroblastoma-derived MYC (MYCN) and multidrug resistance-associated protein 1 (MRP1) as well as downregulating Akt, GSK3beta, and beta-catenin. nobiletin 0-3 AKT serine/threonine kinase 1 Homo sapiens 156-159