PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28152057-7	2017	The nobiletin-induced phase delay was blocked by co-treatment with U0126, an ERK inhibitor.	nobiletin	4-13	mitogen-activated protein kinase 1	Mus musculus	77-80	
30058806-6	2018	The expression levels of p-ERK1/2 and p-p38 mitogen-activated protein kinase (MAPK) in the TPA group were 5.3, 4.8, and 5.7 but downregulated to 2.7, 2.9, and 2.3 in the Nob group and 2.4, 2.7, and 1.2 in the 5-HPMF group, respectively ( p <= 0.05).	nobiletin	170-173	mitogen-activated protein kinase 1	Mus musculus	78-82	
19646972-8	2009	The nobiletin treatment prevented the reduction in CaMKII, MAP2 and GluR1 protein levels in the hippocampal CA1 region, accompanied by restoration of both ERK and CREB phosphorylation and CaMKII autophosphorylation.	nobiletin	4-13	mitogen-activated protein kinase 1	Mus musculus	155-158	
19601643-0	2009	4"-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.	nobiletin	11-20	mitogen-activated protein kinase 1	Mus musculus	72-75	
19601643-0	2009	4"-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.	nobiletin	11-20	mitogen-activated protein kinase 1	Mus musculus	184-187	
19601643-8	2009	Therefore, these results suggest that 4"-demethylnobiletin, a bioactive metabolite of nobiletin, may serve as a potential therapeutic agent, at least, for memory disorders associated with a dysregulated NMDA receptor ERK signaling, like nobiletin.	nobiletin	49-58	mitogen-activated protein kinase 1	Mus musculus	217-220	
19601643-8	2009	Therefore, these results suggest that 4"-demethylnobiletin, a bioactive metabolite of nobiletin, may serve as a potential therapeutic agent, at least, for memory disorders associated with a dysregulated NMDA receptor ERK signaling, like nobiletin.	nobiletin	86-95	mitogen-activated protein kinase 1	Mus musculus	217-220	
17617702-0	2007	Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells.	nobiletin	56-65	mitogen-activated protein kinase 1	Mus musculus	15-52	
17617702-3	2007	Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.	nobiletin	120-129	mitogen-activated protein kinase 1	Mus musculus	31-68	
17617702-3	2007	Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.	nobiletin	120-129	mitogen-activated protein kinase 1	Mus musculus	70-73