PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28478273-0 2017 Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF-kappaB signaling in ischemic brain injury in rats. nobiletin 0-9 AKT serine/threonine kinase 1 Rattus norvegicus 67-70 29334873-11 2018 Nobiletin significantly blocked the activation of Akt/mTOR signaling. nobiletin 0-9 AKT serine/threonine kinase 1 Rattus norvegicus 50-53 30116396-0 2018 Nobiletin protects PC12 cells from ERS-induced apoptosis in OGD/R injury via activation of the PI3K/AKT pathway. nobiletin 0-9 AKT serine/threonine kinase 1 Rattus norvegicus 100-103 30116396-11 2018 Mechanistic detections showed that the neuron-favorable and ERS-repressing contributions of NOB were, in part, a result of the activation of the PI3K/AKT pathway, which was validated by a specific PI3K/AKT inhibitor (LY294002). nobiletin 92-95 AKT serine/threonine kinase 1 Rattus norvegicus 150-153 30116396-11 2018 Mechanistic detections showed that the neuron-favorable and ERS-repressing contributions of NOB were, in part, a result of the activation of the PI3K/AKT pathway, which was validated by a specific PI3K/AKT inhibitor (LY294002). nobiletin 92-95 AKT serine/threonine kinase 1 Rattus norvegicus 202-205 28478273-14 2017 Propofol either alone or with prior nobiletin treatment had down-regulated TLR4 and TLR4-mediated NF-kappaB signaling and caused activation of Akt/mTOR cascade. nobiletin 36-45 AKT serine/threonine kinase 1 Rattus norvegicus 143-146 31082728-0 2019 Nobiletin ameliorates myocardial ischemia and reperfusion injury by attenuating endoplasmic reticulum stress-associated apoptosis through regulation of the PI3K/AKT signal pathway. nobiletin 0-9 AKT serine/threonine kinase 1 Rattus norvegicus 161-164 27840933-7 2016 Treatment with nobiletin induced the activation of phosphorylated (p)-Akt, p-cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) protein expression and reduced the levels of B-cell lymphoma 2-associated X protein (Bax) in isoflurane-induced rats. nobiletin 15-24 AKT serine/threonine kinase 1 Rattus norvegicus 70-73 27840933-8 2016 In conclusion, the present study demonstrated that nobiletin may ameliorate isoflurane-induced cognitive impairment through antioxidant, anti-inflammatory and anti-apoptotic effects via modulation of Akt, Bax, p-CREB and BDNF in aging rats. nobiletin 51-60 AKT serine/threonine kinase 1 Rattus norvegicus 200-203 23644141-0 2013 Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat. nobiletin 0-9 AKT serine/threonine kinase 1 Rattus norvegicus 66-69 23644141-12 2013 Immunohistochemistry, western blot and RT-qPCR analysis indicated that NOB dramatically promoted the activities of Akt, CREB, BDNF and Bcl-2 (P<0.05). nobiletin 71-74 AKT serine/threonine kinase 1 Rattus norvegicus 115-118 23644141-14 2013 On the basis of these findings, we concluded that NOB protected the brain from ischemic damage and it maybe through activating the Akt/CREB signaling pathway and ameliorating BBB permeability. nobiletin 50-53 AKT serine/threonine kinase 1 Rattus norvegicus 131-134 25655748-9 2015 PI3K inhibitor or siRNA targeting of either Akt or NF-kappaB mitigated the impact of nobiletin on MLCK expression and barrier function in Caco-2 monolayer, respectively. nobiletin 85-94 AKT serine/threonine kinase 1 Rattus norvegicus 44-47 25655748-11 2015 Nobiletin restored barrier function, which had been damaged after TNBS administration, through the inhibition of the Akt-NF-kappaB-MLCK pathway. nobiletin 0-9 AKT serine/threonine kinase 1 Rattus norvegicus 117-120 22064360-7 2012 NOB and DTF also activated the ERK, JNK, and Akt pathways in PC12 cells that had undergone serum starvation. nobiletin 0-3 AKT serine/threonine kinase 1 Rattus norvegicus 45-48 22064360-8 2012 Addition of pharmacological kinase inhibitors, U0126, SP600125, and LY294002, caused cytotoxicity and the last significantly attenuated NOB- and DTF-mediated antiapoptotic actions, indicating the involvement of PI3K/Akt signaling in their cytoprotective effects. nobiletin 136-139 AKT serine/threonine kinase 1 Rattus norvegicus 216-219 16465400-8 2006 As a result, hesperetin and nobiletin suppressed the phosphorylation of Akt-1, direct downstream effector of phosphatidylinositol 3-kinase (PI3-K). nobiletin 28-37 AKT serine/threonine kinase 1 Rattus norvegicus 72-77 31082728-9 2019 Importantly, pre-treatment with nobiletin significantly downregulated the myocardial mRNA and protein levels of ERS-related signal molecules, including GRP78, CHOP and caspase-12, but upregulated the levels of p-PI3K and p-AKT. nobiletin 32-41 AKT serine/threonine kinase 1 Rattus norvegicus 223-226 31082728-11 2019 CONCLUSION: Nobiletin pre-treatment may alleviate MIRI probably via the attenuation of PI3K/AKT-mediated ERS-related myocardial apoptosis. nobiletin 12-21 AKT serine/threonine kinase 1 Rattus norvegicus 92-95 30951715-6 2019 Furthermore, we observed that pretreatment with nobiletin significantly activated the Akt/GSK-3beta signaling pathway in H/R-stimulated H9c2 cells. nobiletin 48-57 AKT serine/threonine kinase 1 Rattus norvegicus 86-89 30951715-7 2019 Taken together, these findings demonstrated that nobiletin attenuates myocardial I/R injury via the activation of Akt/GSK-3beta pathway in H9c2 cardiomyocytes. nobiletin 49-58 AKT serine/threonine kinase 1 Rattus norvegicus 114-117