PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22042506-6	2012	These results indicate that isorhynchophylline exerts a neuroprotective effect against Abeta(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative stress and suppressing the mitochondrial pathway of cellular apoptosis.	rhyncophylline	28-46	amyloid beta precursor protein	Rattus norvegicus	87-92	
22042506-3	2012	The present study aimed to evaluate the protective effect of isorhynchophylline, an oxindole alkaloid isolated from a Chinese herb Uncaria rhynchophylla, on Abeta-induced neurotoxicity in cultured rat pheochromocytoma (PC12) cells.	rhyncophylline	61-79	amyloid beta precursor protein	Rattus norvegicus	157-162	
22042506-4	2012	The results showed that pretreatment with isorhynchophylline significantly elevated cell viability, decreased the levels of intracellular reactive oxygen species and malondialdehyde, increased the level of glutathione, and stabilized mitochondrial membrane potential in Abeta(25-35)-treated PC12 cells.	rhyncophylline	42-60	amyloid beta precursor protein	Rattus norvegicus	270-275	
22778778-6	2012	Among them, rhynchophylline and isorhynchophylline significantly decreased Abeta-induced cell death, intracellular calcium overloading, and tau protein hyperphosphorylation in PC12 cells.	rhyncophylline	12-27	amyloid beta precursor protein	Rattus norvegicus	75-80	
22778778-6	2012	Among them, rhynchophylline and isorhynchophylline significantly decreased Abeta-induced cell death, intracellular calcium overloading, and tau protein hyperphosphorylation in PC12 cells.	rhyncophylline	32-50	amyloid beta precursor protein	Rattus norvegicus	75-80	
22778778-7	2012	These results suggest that rhynchophylline and isorhynchophylline are the major active ingredients responsible for the protective action of Uncaria rhynchophylla against Abeta-induced neuronal toxicity, and their neuroprotective effect may be mediated, at least in part, by inhibiting intracellular calcium overloading and tau protein hyperphosphorylation.	rhyncophylline	27-42	amyloid beta precursor protein	Rattus norvegicus	170-175	
22778778-7	2012	These results suggest that rhynchophylline and isorhynchophylline are the major active ingredients responsible for the protective action of Uncaria rhynchophylla against Abeta-induced neuronal toxicity, and their neuroprotective effect may be mediated, at least in part, by inhibiting intracellular calcium overloading and tau protein hyperphosphorylation.	rhyncophylline	47-65	amyloid beta precursor protein	Rattus norvegicus	170-175