PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35492370-2	2022	Since the decrease of hypoxia inducible factor-1alpha (HIF-1alpha) is reported to be involved in Hcy-induced cell injury, and the upregulation of microRNA-223 (miR-223) plays a vital protective role in the impairment of IBF in the experimental colitis, we investigated the effect of HIF-1alpha stabilizer roxadustat on the disruption of TJPs induced by Hcy and CKD and the underlying mechanism.	roxadustat	305-315	microRNA 223	Homo sapiens	146-158	
35492370-2	2022	Since the decrease of hypoxia inducible factor-1alpha (HIF-1alpha) is reported to be involved in Hcy-induced cell injury, and the upregulation of microRNA-223 (miR-223) plays a vital protective role in the impairment of IBF in the experimental colitis, we investigated the effect of HIF-1alpha stabilizer roxadustat on the disruption of TJPs induced by Hcy and CKD and the underlying mechanism.	roxadustat	305-315	microRNA 223	Homo sapiens	160-167	
35492370-8	2022	The reduction of HIF-1alpha and miR-223 was reversed by roxadustat and the decrease of TJPs expression was attenuated in both Caco2 cells induced by Hcy and colon tissue of CKD rats.	roxadustat	56-66	microRNA 223	Homo sapiens	32-39