PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26238121-12	2015	CONCLUSIONS: Roxadustat transiently and moderately increased endogenous erythropoietin and reduced hepcidin.	roxadustat	13-23	hepcidin antimicrobial peptide	Homo sapiens	99-107	
27094610-1	2016	BACKGROUND AND OBJECTIVES: Roxadustat (FG-4592), an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis, regulates iron metabolism, and reduces hepcidin, was evaluated in this phase 2b study for safety, efficacy, optimal dose, and dose frequency in patients with nondialysis CKD.	roxadustat	27-37	hepcidin antimicrobial peptide	Homo sapiens	182-190	
27094610-15	2016	CONCLUSIONS: In patients with nondialysis CKD who were anemic, various starting dose regimens of roxadustat were well tolerated and achieved anemia correction with reduced serum hepcidin levels.	roxadustat	97-107	hepcidin antimicrobial peptide	Homo sapiens	178-186	
26494833-11	2016	In summary, roxadustat was well tolerated and corrected anemia in incident HD and PD patients, regardless of baseline iron repletion status or C-reactive protein level and with oral or IV iron supplementation; it also reduced serum hepcidin levels.	roxadustat	12-22	hepcidin antimicrobial peptide	Homo sapiens	232-240	
26846333-1	2016	BACKGROUND: Roxadustat (FG-4592) is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin.	roxadustat	12-22	hepcidin antimicrobial peptide	Homo sapiens	213-221	
26846333-11	2016	Hepcidin level reduction was greater at roxadustat 2.0mg/kg versus epoetin alfa (P<0.05).	roxadustat	40-50	hepcidin antimicrobial peptide	Homo sapiens	0-8	
34167878-10	2022	Roxadustat decreased hepcidin levels and increased total iron-binding capacity.	roxadustat	0-10	hepcidin antimicrobial peptide	Homo sapiens	21-29	
32309288-9	2020	On the other hand, roxadustat also improves iron metabolism by decreasing serum hepcidin and increasing intestinal iron absorption, which is beneficial to functional iron deficiency and absolute iron deficiency.	roxadustat	19-29	hepcidin antimicrobial peptide	Homo sapiens	80-88	
33389461-9	2021	In addition, our result showed that a significant reduction in hepcidin level (- 31.96 ng/mL, 95% CI [- 35.05 ng/mL, - 28.87 ng/mL], p < 0.00001), ferritin (- 44.82 ng/mL, 95% CI [- 64.42 ng/mL, - 25.23 ng/mL], p < 0.00001) was associated with roxadustat.	roxadustat	244-254	hepcidin antimicrobial peptide	Homo sapiens	63-71	
33051677-8	2021	Hepcidin levels were reduced significantly in the roxadustat group versus those in the placebo [SMD -1.72 (95% CI -3.03 to -0.41), very low-quality evidence] or epoetin alfa group [SMD -0.23 (95% CI -0.43 to -0.02), low-quality evidence].	roxadustat	50-60	hepcidin antimicrobial peptide	Homo sapiens	0-8	
32309288-13	2020	Roxadustat corrects anemia of CKD patients through multiple pathways, beyond elevating EPO levels within physiological range, and also by handling iron metabolism (particularly decreasing the hepcidin levels).	roxadustat	0-10	hepcidin antimicrobial peptide	Homo sapiens	192-200	
31340089-9	2019	The mean reduction from baseline in the hepcidin level (associated with greater iron availability) was 56.14+-63.40 ng per milliliter in the roxadustat group and 15.10+-48.06 ng per milliliter in the placebo group.	roxadustat	141-151	hepcidin antimicrobial peptide	Homo sapiens	40-48