PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31759089-4 2020 In this study, we found that GPS significantly reversed the downregulation of TGR5 and inhibited the overproduction of fibronectin (FN), transforming growth factor beta1 (TGF-beta1), intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) in glomerular mesangial cells (GMCs) exposed to high glucose (HG). gentiopicroside 29-32 vascular cell adhesion molecule 1 Mus musculus 230-258 31759089-4 2020 In this study, we found that GPS significantly reversed the downregulation of TGR5 and inhibited the overproduction of fibronectin (FN), transforming growth factor beta1 (TGF-beta1), intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) in glomerular mesangial cells (GMCs) exposed to high glucose (HG). gentiopicroside 29-32 vascular cell adhesion molecule 1 Mus musculus 260-266 31759089-7 2020 Importantly, the depletion of TGR5 blocked the inhibition of the NF-kappaB signalling pathway and reversed the downregulation of FN, ICAM-1, VCAM-1 and TGF-beta1 by GPS in HG-induced GMCs. gentiopicroside 165-168 vascular cell adhesion molecule 1 Mus musculus 141-147