PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26174134-3	2015	In the accompanying paper a polysomnographic electroencephalography (sleep-EEG) study of vortioxetine and paroxetine in healthy subjects indicated that at low/intermediate levels of SERT occupancy, vortioxetine affected rapid eye movement (REM) sleep differently than paroxetine.	Vortioxetine	89-101	solute carrier family 6 member 4	Rattus norvegicus	182-186	
27106166-1	2016	The antidepressant vortioxetine is a 5-HT3-R, 5-HT7-R and 5-HT1D-R antagonist, 5-HT1B-R partial agonist, 5-HT1A-R agonist, and serotonin (5-HT) transporter (SERT) inhibitor.	Vortioxetine	19-31	solute carrier family 6 member 4	Rattus norvegicus	157-161	
28407315-5	2017	Sustained vortioxetine or fluoxetine (at doses aimed to fully occupy serotonin transporter via food or drinking water for at least 14 days) reduced levels of the excitotoxin quinolinic acid (QUIN) in various brain regions in all rats.	Vortioxetine	10-22	solute carrier family 6 member 4	Rattus norvegicus	69-90	
26174134-4	2015	Here we investigated clinically meaningful doses (80-90% SERT occupancy) of vortioxetine and paroxetine on sleep-EEG in rats to further elucidate the serotoninergic receptor mechanisms mediating this difference.	Vortioxetine	76-88	solute carrier family 6 member 4	Rattus norvegicus	57-61	
23089374-2	2013	Here, we report the effects of the multi-modal antidepressant vortioxetine (Lu AA21004), a 5-HT(3) and 5-HT(7) receptor antagonist, 5-HT(1B) receptor partial agonist, 5-HT(1A) receptor agonist and 5-HT transporter (SERT) inhibitor, on rat 5-HT neurotransmission.	Vortioxetine	62-74	solute carrier family 6 member 4	Rattus norvegicus	215-219	
25524057-2	2015	Vortioxetine is a multimodal acting antidepressant that functions as a 5-HT3 and 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and inhibitor of the 5-HT transporter.	Vortioxetine	0-12	solute carrier family 6 member 4	Rattus norvegicus	197-213	
25122043-1	2014	Vortioxetine, a novel antidepressant with multimodal action, is a serotonin (5-HT)3, 5-HT7 and 5-HT1D receptor antagonist, a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist and a 5-HT transporter (SERT) inhibitor.	Vortioxetine	0-12	solute carrier family 6 member 4	Rattus norvegicus	190-206	
25122043-1	2014	Vortioxetine, a novel antidepressant with multimodal action, is a serotonin (5-HT)3, 5-HT7 and 5-HT1D receptor antagonist, a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist and a 5-HT transporter (SERT) inhibitor.	Vortioxetine	0-12	solute carrier family 6 member 4	Rattus norvegicus	208-212	
23089374-14	2013	This is at least partly due to 5-HT(3) receptor antagonism of vortioxetine in association with its reduced SERT occupancy.	Vortioxetine	62-74	solute carrier family 6 member 4	Rattus norvegicus	107-111	
29269186-10	2018	These observations support the hypothesis that vortioxetine"s antidepressant activity may involve mechanisms beyond SERT inhibition.	Vortioxetine	47-59	solute carrier family 6 member 4	Rattus norvegicus	116-120	
34358549-2	2021	Vortioxetine (VTX) is a multimodal antidepressant agent that balances 5-HT receptors and represses the serotonin transporter.	Vortioxetine	0-12	solute carrier family 6 member 4	Rattus norvegicus	103-124	
34358549-2	2021	Vortioxetine (VTX) is a multimodal antidepressant agent that balances 5-HT receptors and represses the serotonin transporter.	Vortioxetine	14-17	solute carrier family 6 member 4	Rattus norvegicus	103-124	
35146812-1	2022	The antidepressant vortioxetine has high affinity for the ionotropic 5-HT3 receptor (5-HT3 R) as well as other targets including the 5-HT transporter.	Vortioxetine	19-31	solute carrier family 6 member 4	Rattus norvegicus	133-149	
31314843-1	2019	Vortioxetine is a multimodal antidepressant agent that modulates 5-HT receptors and inhibits the serotonin transporter.	Vortioxetine	0-12	solute carrier family 6 member 4	Rattus norvegicus	97-118	
23380522-2	2013	Vortioxetine (Lu AA21004) in development as a novel multimodal antidepressant is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist and a 5-HT transporter (5-HTT) inhibitor in vitro.	Vortioxetine	0-12	solute carrier family 6 member 4	Rattus norvegicus	195-211	
29104073-1	2018	The antidepressant vortioxetine exerts its effects via modulation of several serotonin (5-HT) receptors and inhibition of the 5-HT transporter (SERT).	Vortioxetine	19-31	solute carrier family 6 member 4	Rattus norvegicus	126-142	
29104073-1	2018	The antidepressant vortioxetine exerts its effects via modulation of several serotonin (5-HT) receptors and inhibition of the 5-HT transporter (SERT).	Vortioxetine	19-31	solute carrier family 6 member 4	Rattus norvegicus	144-148