PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22138579-7 2012 The A(2A) receptor agonist, CGS21680, inhibited osteoclast differentiation and function (half maximal inhibitory concentration, 50 nmol/L), increased the percentage of immature osteoclast precursors, and decreased IL-1beta and tumor necrosis factor-alpha secretion, an effect that was reversed by the A(2A) antagonist, ZM241385. 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 28-36 interleukin 1 beta Mus musculus 214-254 35046793-11 2021 Under low-glucose and hypoxic conditions, CGS21680 treatment promoted macrophage M2 polarization, increased the expression of PPARgamma, P65, and interleukin-10 (IL-10) and suppressed the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 42-50 interleukin 1 beta Mus musculus 246-263