PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32308059-5	2020	In neurons, the AntiA2AR reversed the calcium flow change induced by the A2AR agonist CGS21680 (1muM).	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	86-94	adenosine A2a receptor	Homo sapiens	20-24	
32785947-5	2021	In the present study, the administration of the highly selective A2A R agonist (CGS21680) and antagonist (SCH58261) were utilized to investigate the function of A2A R under general anesthesia induced by propofol by means of animal behavior studies, resting state magnetic resonance imaging (rsfMRI) and c-Fos immunofluorescence staining approaches.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	80-88	adenosine A2a receptor	Homo sapiens	65-70	
31278313-6	2019	The A2AR agonist CGS21680 normalized all NPC1-like features.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	17-25	adenosine A2a receptor	Homo sapiens	4-8	
31366130-9	2019	Especifically, chronic administration of CBZ and CGS21680 prevented the reduction and elevation of A2AR expression by respective IFNgamma and TNFalpha.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	49-57	adenosine A2a receptor	Homo sapiens	99-103	
32440820-8	2020	Exosome production from cancer cells was reduced (p = 0.0028) by the selective A2AR agonist CGS 21680.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	92-101	adenosine A2a receptor	Homo sapiens	79-83	
25762024-0	2015	Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	26-34	adenosine A2a receptor	Homo sapiens	56-78	
30336179-7	2019	A2AR agonist CGS21680 increased Rap1gap phosphorylation, and pretreatment with the D2R agonist quinpirole blocked this effect in striatal slices.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	13-21	adenosine A2a receptor	Homo sapiens	0-4	
29790247-5	2018	Adenosine A2a receptor agonist CGS21680 promoted the secretion of more proangiogenic factors from MM, inducing EPC migration and mobilization.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	31-39	adenosine A2a receptor	Homo sapiens	0-22	
28743501-9	2017	However, the protective effect of hypoxia postconditioning treatment could be inhibited by adding CGS21680, a selective adenosine A2a receptor agonist (all P values < 0.05).	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	98-106	adenosine A2a receptor	Homo sapiens	120-142	
24068806-4	2013	The aim of this study was to evaluate the effects of the A2AR agonist CGS21680 on human control and NPC1 fibroblasts.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	70-78	adenosine A2a receptor	Homo sapiens	57-61	
25458315-4	2015	Agonist CGS21680 targeting A2AR could effectively inhibit the maturation and activation of reoxygenated DCs through downregulating the expression of MHC class II molecules and CD86.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	8-16	adenosine A2a receptor	Homo sapiens	27-31	
24200882-3	2014	Here, we show that in primary normal human dermal fibroblasts, A2AR stimulation with CGS21680 elicits a modest cAMP increase (150 +- 12% of control; EC50 54.8 nM), which stimulates collagen1 (Col1) and collagen3 (Col3), but maximal cAMP resulting from direct activation of adenylyl cyclase by forskolin (15,689 +- 7038% of control; EC50 360.7 nM) inhibits Col1 and increases Col3.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	85-93	adenosine A2a receptor	Homo sapiens	63-67	
16917093-9	2006	The effect of adenosine was mimicked by the adenosine A2a receptor agonist CGS21680 and was inhibited by both the A2a antagonist SCH5826 and A2a RNA silencing.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	75-83	adenosine A2a receptor	Homo sapiens	44-66	
23461670-5	2013	The protective effects of caffeine in SH-SY5Y cells disappeared with co-treatment by the adenosine A2A receptor agonist, CGS21680, and were mimicked by the adenosine A2A R antagonist, SCH58261.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	121-129	adenosine A2a receptor	Homo sapiens	89-111	
23583199-4	2013	The adenosine A2A receptor agonist CGS21680 caused intracellular calcium mobilization in controls and, to a greater extent, in A2A receptor-overexpressing HLMVECs.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	35-43	adenosine A2a receptor	Homo sapiens	4-26	
17575165-4	2007	Studies with CGS21680, a specific agonist of adenosine A2A receptor (AdoRA2A), and ZM241385, an AdoRA2-selective antagonist, indicate that the inhibitory effects of adenosine are mediated via cyclic AMP (cAMP)-elevating AdoRA2A, leading to protein kinase A (PKA) activation.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	13-21	adenosine A2a receptor	Homo sapiens	45-67	
17575165-4	2007	Studies with CGS21680, a specific agonist of adenosine A2A receptor (AdoRA2A), and ZM241385, an AdoRA2-selective antagonist, indicate that the inhibitory effects of adenosine are mediated via cyclic AMP (cAMP)-elevating AdoRA2A, leading to protein kinase A (PKA) activation.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	13-21	adenosine A2a receptor	Homo sapiens	69-76	
17575165-4	2007	Studies with CGS21680, a specific agonist of adenosine A2A receptor (AdoRA2A), and ZM241385, an AdoRA2-selective antagonist, indicate that the inhibitory effects of adenosine are mediated via cyclic AMP (cAMP)-elevating AdoRA2A, leading to protein kinase A (PKA) activation.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	13-21	adenosine A2a receptor	Homo sapiens	69-75	
34311536-5	2021	GF and EC were stimulated with LPS (2 mug/ml) alone or in combination with i) PDRN (100 mug/ml); ii) PDRN plus ZM241385 (1 muM) as an A2AR antagonist; iii) CGS21680 (1 muM) as an A2AR agonist.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	156-164	adenosine A2a receptor	Homo sapiens	179-183	
15239970-2	2004	In this study the adenosine A2A receptor agonist CGS21680 was used to evaluate adenosine receptor specificity and the interrelation of adenosine and GABA in the inhibition of inspiratory drive.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	49-57	adenosine A2a receptor	Homo sapiens	18-40	
35571159-11	2022	Activated A2aR with its agonist CGS21680 before reperfusion saved cellular survival through anti-apoptosis and anti-autophagy effect, thus improving ventricular contraction disorders, and visibly reducing myocardial infarction size.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	32-40	adenosine A2a receptor	Homo sapiens	10-14