PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25897233-1	2015	PURPOSE: This study investigated the relationships among the plasma levels of catecholamine metabolites, the clinical response to duloxetine treatment, and Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene.	Duloxetine Hydrochloride	130-140	catechol-O-methyltransferase	Homo sapiens	186-214	
25897233-1	2015	PURPOSE: This study investigated the relationships among the plasma levels of catecholamine metabolites, the clinical response to duloxetine treatment, and Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene.	Duloxetine Hydrochloride	130-140	catechol-O-methyltransferase	Homo sapiens	216-220	
25897233-14	2015	CONCLUSION: The relationship among the COMT Val158Met polymorphism, plasma levels of catecholamine metabolites, and responses to duloxetine is complex.	Duloxetine Hydrochloride	129-139	catechol-O-methyltransferase	Homo sapiens	39-43	
22727709-1	2012	In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed.	Duloxetine Hydrochloride	97-107	catechol-O-methyltransferase	Homo sapiens	258-262	
21788083-0	2011	Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder.	Duloxetine Hydrochloride	58-68	catechol-O-methyltransferase	Homo sapiens	15-43	
21788083-1	2011	Single-nucleotide and diplotype associations with 17-item Hamilton Depression Rating Scale (HAMD(17)) total score changes were examined, based on catechol-O-methyltransferase (COMT) rs165599 status in duloxetine-treated, self-identified white patients with major depressive disorder.	Duloxetine Hydrochloride	201-211	catechol-O-methyltransferase	Homo sapiens	146-174	
19095219-0	2009	Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder.	Duloxetine Hydrochloride	61-71	catechol-O-methyltransferase	Homo sapiens	13-41	
19095219-10	2009	CONCLUSIONS: Single nucleotide polymorphisms in COMT were associated with symptom change in duloxetine-treated patients with MDD.	Duloxetine Hydrochloride	92-102	catechol-O-methyltransferase	Homo sapiens	48-52