PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35609321-7	2022	Lastly, the promoted expression levels of p-JAK-2/JAK-2 and p-STAT3/STAT-3 in the cardiac tissues of ISO-challenged mice were significantly repressed by Pirfenidone or SPI.	pirfenidone	153-164	signal transducer and activator of transcription 3	Mus musculus	62-67	
35609321-7	2022	Lastly, the promoted expression levels of p-JAK-2/JAK-2 and p-STAT3/STAT-3 in the cardiac tissues of ISO-challenged mice were significantly repressed by Pirfenidone or SPI.	pirfenidone	153-164	signal transducer and activator of transcription 3	Mus musculus	68-74	
34316030-7	2022	Mechanistically, antibody array and bioinformatic analysis showed that the pathways related to IL-17 secretion, including JAK-STAT pathway, Th17 differentiation, and IL-17 pathway, might be involved in the treatment of silicosis by pirfenidone.	pirfenidone	232-243	signal transducer and activator of transcription 3	Mus musculus	126-130	
34316030-8	2022	Further in vivo experiments confirmed that pirfenidone reduced the production of IL-17A induced by silica exposure via inhibiting STAT3 phosphorylation.	pirfenidone	43-54	signal transducer and activator of transcription 3	Mus musculus	130-135	
35609321-0	2022	Pirfenidone attenuates cardiac hypertrophy against isoproterenol by inhibiting activation of the janus tyrosine kinase-2/signal transducer and activator of transcription 3 (JAK-2/STAT3) signaling pathway.	pirfenidone	0-11	signal transducer and activator of transcription 3	Mus musculus	97-171	
35609321-0	2022	Pirfenidone attenuates cardiac hypertrophy against isoproterenol by inhibiting activation of the janus tyrosine kinase-2/signal transducer and activator of transcription 3 (JAK-2/STAT3) signaling pathway.	pirfenidone	0-11	signal transducer and activator of transcription 3	Mus musculus	179-184