PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26343583-3 2015 LY3009120 induces BRAF-CRAF dimerization but inhibits the phosphorylation of downstream MEK and ERK, suggesting that it effectively inhibits the kinase activity of BRAF-CRAF heterodimers. LY3009120 0-9 mitogen-activated protein kinase kinase 7 Homo sapiens 88-91 34837846-9 2022 MEK inhibitor showed synergy with multikinase inhibitor ponatinib, ABL inhibitor nilotinib, PI3K/mTOR inhibitor pictilisib, and pan-RAF inhibitor LY3009120. LY3009120 146-155 mitogen-activated protein kinase kinase 7 Homo sapiens 0-3 34539849-7 2021 This effect was caused by a decrease in proliferation, induction of apoptosis, and cell growth arrest through a decrease in phosphorylated MEK and ERK along with a cytotoxic response occurring specifically for the RAS mutation of the pan-RAF inhibitor LY3009120. LY3009120 252-261 mitogen-activated protein kinase kinase 7 Homo sapiens 139-142