PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33868466-6 2021 Both cell types exhibited a slight decrease in viability following increasing doses of IR; the chondrosarcoma cells demonstrated a significant dose-dependent increase in the expression levels of the DNA damage marker histone H2AX phosphorylation at serine 139 (gammaH2AX). gammah2ax 261-270 H2A.X variant histone Homo sapiens 217-229 31045206-1 2019 Histone H2AX undergoes a phosphorylation switch from pTyr142 (H2AX-pY142) to pSer139 (gammaH2AX) in the DNA damage response (DDR); however, the functional role of H2AX-pY142 remains elusive. gammah2ax 86-95 H2A.X variant histone Homo sapiens 8-12 30031728-4 2018 Markers of generic and oxidative DNA damage [phosphorylated histone H2AX (gammaH2AX) and 8-hydroxy-2"-deoxyguanosine (8-OHdG)] were significantly higher in liver metastases compared with their corresponding primary tumors. gammah2ax 74-83 H2A.X variant histone Homo sapiens 60-72 26928355-4 2016 We demonstrated that the inhibition of CPT-induced MDC1 foci formation by PG was caused by the direct suppression of histone H2AX phosphorylation at Ser139 (gammaH2AX), which is required for MDC1 foci formation, by quantifying gammaH2AX in cells and in vitro 9-AA also directly suppressed H2AX Ser139-phosphorylation in vitro but the concentration was much higher than that required to suppress CPT-induced MDC1 foci formation in cells. gammah2ax 157-166 H2A.X variant histone Homo sapiens 125-129 29529298-4 2018 Chromatin immunoprecipitation following a single DSB shows that the reduced levels of gammaH2AX accumulation at DSBs in CHD1-KO cells are due to both a global reduction in H2AX incorporation and poor retention of H2AX at the DSBs. gammah2ax 86-95 H2A.X variant histone Homo sapiens 172-176 30103844-7 2018 Phosphorylated H2AX (gammaH2AX) foci assay demonstrate that both resveratrol and cisplatin treatment result in a significant increase of gammaH2AX foci in hepatoma cells, and the resveratrol and cisplatin combined treatment results in much more gammaH2AX foci formation than either resveratrol or cisplatin treatment alone. gammah2ax 21-30 H2A.X variant histone Homo sapiens 15-19 29970961-3 2018 Patients and methods: The levels of phosphorylated H2AX (gammaH2AX), a molecule that promotes DNA repair, were assessed in vastus lateralis biopsies from 10 COPD patients with low fat-free mass index (FFMI; COPDL), 10 with preserved FFMI and 10 age- and gender-matched healthy controls. gammah2ax 57-66 H2A.X variant histone Homo sapiens 51-55 26667983-2 2016 H2AX is a histone protein directly associated with DNA that is phosphorylated to produce gammaH2AX that accumulates in foci in an early response to DNA double-strand breaks, the most deleterious lesion caused by anticancer therapy. gammah2ax 89-98 H2A.X variant histone Homo sapiens 0-4 26819332-2 2016 One of the earliest molecular responses following DSB formation is the phosphorylation of the histone H2AX, giving rise to gammaH2AX. gammah2ax 123-132 H2A.X variant histone Homo sapiens 102-106 26189260-2 2015 OBJECTIVE: This study aimed to determine whether phosphorylation of histone H2AX (gammaH2AX) is a predictive marker for neoadjuvant chemotherapy patients of cervical cancer. gammah2ax 82-91 H2A.X variant histone Homo sapiens 68-80 26119999-2 2015 Here, we discover a bromodomain (BRD)-like module in DNA-PKcs (DNA-PKcs-BRD) that specifically recognizes H2AX acetyl-lysine 5 (K5ac) for sequential induction of gammaH2AX and concurrent cell fate decision(s). gammah2ax 162-171 H2A.X variant histone Homo sapiens 106-110 26119999-3 2015 First, top-down mass spectrometry of radiation-phenotypic, full-length H2AX revealed a radiation-inducible, K5ac-dependent induction of gammaH2AX. gammah2ax 136-145 H2A.X variant histone Homo sapiens 71-75 23620287-3 2013 As the locally restricted phosphorylation of H2AX to form gammaH2AX is a key step in facilitating efficient DSB repair, we investigated this process after localized induction of clustered damage by ionizing radiation. gammah2ax 58-67 H2A.X variant histone Homo sapiens 45-49 23916969-1 2013 Chromosomal double strand breaks provoke an extensive reaction in neighboring chromatin, characterized by phosphorylation of histone H2AX on serine 139 of its C-terminal tail (to form "gammaH2AX"). gammah2ax 185-194 H2A.X variant histone Homo sapiens 125-137 24352470-4 2014 Phosphorylated H2AX (gammaH2AX) colocalized at 30 min (0.5 h) with the KSHV genome entering the nuclei. gammah2ax 21-30 H2A.X variant histone Homo sapiens 15-19 24163101-2 2014 Here we demonstrate that H2AX is dynamically reorganized to preoccupy gammaH2AX hotspots on increased replication stress by activated cell proliferation and that H2AX is enriched in aphidicolin-induced replisome stalling sites in cycling cells. gammah2ax 70-79 H2A.X variant histone Homo sapiens 25-29 19455703-3 2009 H2AX is immediately activated by ATM in response to DNA damage and its phosphorylated form, gammaH2AX, flanks the DSB through several megabases. gammah2ax 92-101 H2A.X variant histone Homo sapiens 0-4 21566653-7 2011 Treatment with wortmannin decreased phosphorylation of H2AX and suggests phosphoinositide (PI) 3-kinases and/or PI3-kinase-like family members underlie the presence of gammaH2AX foci in MM cells. gammah2ax 168-177 H2A.X variant histone Homo sapiens 55-59 20736911-3 2010 The phosphorylated form of H2AX, referred to as gammaH2AX, spreads to adjacent regions of chromatin from the site of the DSB, forming discrete foci, which are easily visualized by immunofluorescence microscopy. gammah2ax 48-57 H2A.X variant histone Homo sapiens 27-31 20372103-2 2010 An early response to the induction of DSBs is phosphorylation of the H2A histone variant, H2AX, at the serine-139 residue, in the highly conserved C-terminal SQEY motif, forming gammaH2AX(1). gammah2ax 178-187 H2A.X variant histone Homo sapiens 90-94 21261999-4 2011 Radiation exposure often results in the formation of DNA double-strand breaks, which are marked by the induction of H2AX phosphorylation to generate gammaH2AX. gammah2ax 149-158 H2A.X variant histone Homo sapiens 116-120 21184737-3 2011 We found that TrkA co-localizes with ectopically expressed GFP-H2AX proteins in the cytoplasm, especially at the juxta-nuclear membranes, which supports our previous results about a functional connection between TrkA and gammaH2AX in TrkA-induced cell death. gammah2ax 221-230 H2A.X variant histone Homo sapiens 63-67 20978201-6 2010 The attenuated gammaH2AX response seems to result from low levels of total H2A.X in the luminal cells. gammah2ax 15-24 H2A.X variant histone Homo sapiens 75-80 20492564-4 2010 Acute UVB irradiation of human keratinocytes increased the phosphorylation of H2AX in a dose-dependent manner; two types of gammaH2AX response were observed either in vitro or in vivo. gammah2ax 124-133 H2A.X variant histone Homo sapiens 78-82 20150765-2 2010 Rapid phosphorylation of the histone variant H2AX at Ser-139 to form gammaH2AX is an early cellular response to DNA double-strand breaks. gammah2ax 69-78 H2A.X variant histone Homo sapiens 45-49 18645678-1 2008 AIM: To investigate whether adriamycin induces DNA damage and the formation of gammaH2AX (the phosphorylated form of histone H2AX) foci in mature spermatozoa. gammah2ax 79-88 H2A.X variant histone Homo sapiens 117-129 18647348-4 2008 The C-terminal tail of histone 2AX (H2AX) is hyperphosphorylated in the same mutants, and Pph3p is found to interact with phosphorylated H2AX (gammaH2AX). gammah2ax 143-152 H2A.X variant histone Homo sapiens 23-34 18647348-4 2008 The C-terminal tail of histone 2AX (H2AX) is hyperphosphorylated in the same mutants, and Pph3p is found to interact with phosphorylated H2AX (gammaH2AX). gammah2ax 143-152 H2A.X variant histone Homo sapiens 36-40 18647348-4 2008 The C-terminal tail of histone 2AX (H2AX) is hyperphosphorylated in the same mutants, and Pph3p is found to interact with phosphorylated H2AX (gammaH2AX). gammah2ax 143-152 H2A.X variant histone Homo sapiens 137-141 16098182-6 2005 The induction of double-strand DNA breaks (DSBs) by genotoxic agents provides a signal for histone H2AX phosphorylation on Ser139; the phosphorylated H2AX is named gammaH2AX. gammah2ax 164-173 H2A.X variant histone Homo sapiens 99-103 17969164-3 2007 Flow cytometry was used to quantify gammaH2AX (serine 139 phosphorylated form of histone H2AX) expression of antibody-stained cells as a marker for deoxyribonucleic acid (DNA) DSBs one hour and 24 hours after magnetic field exposure. gammah2ax 36-45 H2A.X variant histone Homo sapiens 81-93 17185671-1 2007 PURPOSE: To prospectively determine if gammaH2AX (phosphorylated form of H2AX histone variant)-based visualization and quantification of DNA damage induced in peripheral blood mononuclear cells (PBMCs) can be used to estimate the radiation dose received by adult patients who undergo multidetector computed tomography (CT). gammah2ax 39-48 H2A.X variant histone Homo sapiens 73-85 16820894-2 2006 Phosphorylated H2AX has been named gammaH2AX, and induction of gammaH2AX in cells exposed to genotoxic agents is considered a sensitive and specific reporter of DNA damage. gammah2ax 35-44 H2A.X variant histone Homo sapiens 15-19 16820894-2 2006 Phosphorylated H2AX has been named gammaH2AX, and induction of gammaH2AX in cells exposed to genotoxic agents is considered a sensitive and specific reporter of DNA damage. gammah2ax 63-72 H2A.X variant histone Homo sapiens 15-19 17064697-8 2006 Collectively, these results demonstrate that oxidative stress can induce H2AX phosphorylation in human spermatozoa through DSB induction, and that gammaH2AX may be used as a sensitive, novel marker for such DSBs. gammah2ax 147-156 H2A.X variant histone Homo sapiens 73-77 16685450-3 2006 Phosphorylated H2AX (gammaH2AX) can be detected immunocytochemically, and the intensity of gammaH2AX immunofluorescence (IF), reflecting the number of gammaH2AX-IF foci per nucleus, reveals the frequency of DSBs. gammah2ax 21-30 H2A.X variant histone Homo sapiens 15-19 16098182-6 2005 The induction of double-strand DNA breaks (DSBs) by genotoxic agents provides a signal for histone H2AX phosphorylation on Ser139; the phosphorylated H2AX is named gammaH2AX. gammah2ax 164-173 H2A.X variant histone Homo sapiens 150-154 15655354-2 2005 Expression of phosphorylated H2AX (gammaH2AX) can be revealed immunocytochemically; the intensity of gammaH2AX immunofluorescence (IF) measured by cytometry was reported to correlate with the frequency of DSBs induced by X-ray radiation or by DNA damaging antitumor drugs. gammah2ax 35-44 H2A.X variant histone Homo sapiens 29-33 15604242-1 2004 To identify critical events associated with heat-induced cell killing, we examined foci formation of gammaH2AX (histone H2AX phosphorylated at serine 139) in heat-treated cells. gammah2ax 101-110 H2A.X variant histone Homo sapiens 112-124 15455410-2 2004 Phosphorylated H2AX, denoted as gammaH2AX, can be detected immunocytochemically using an antibody that is specific to the Ser-139-phosphorylated epitope. gammah2ax 32-41 H2A.X variant histone Homo sapiens 15-19