PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10997694-6	2000	Furthermore, PD98059, a specific inhibitor of MAPK/ERK kinase (MEK), can inhibit this TGF-beta-induced fibronectin expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	13-20	transforming growth factor, beta 1	Rattus norvegicus	86-94	
12029621-3	2002	TGF-beta1-induced apoptosis was markedly enhanced when ERK activation was selectively inhibited by the mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	191-198	transforming growth factor, beta 1	Rattus norvegicus	0-9	
11716483-8	2001	Serum treatment (10%) attenuated the TGF-beta-induced Smad7 mRNA increase, and PD98059 (30 microM) treatment increased the basal and TGF-beta-induced Smad7 promoter activity.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	79-86	transforming growth factor, beta 1	Rattus norvegicus	133-141	
11401854-8	2001	TGF-beta"s stimulation of ERK activation was blocked by PD-98059, an inhibitor of MAP kinase kinase 1, and by adenoviral transfer of dominant negative RasN17.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	56-64	transforming growth factor, beta 1	Rattus norvegicus	0-8	
11401854-10	2001	The biological relevance of ERK activation by TGF-beta was indicated by demonstrating that inhibition of ERK signaling by PD-98059 blocked the ability of TGF-beta to activate the transcription factor activator protein-1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	122-130	transforming growth factor, beta 1	Rattus norvegicus	46-54	
11401854-10	2001	The biological relevance of ERK activation by TGF-beta was indicated by demonstrating that inhibition of ERK signaling by PD-98059 blocked the ability of TGF-beta to activate the transcription factor activator protein-1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	122-130	transforming growth factor, beta 1	Rattus norvegicus	154-162	
12206991-6	2002	PD-098059, a MEK1 inhibitor, and SB-203580, an inhibitor of p38 MAPKalpha-gamma, diminished NOS3 expression and production of TGF-beta1 and NOx.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-9	transforming growth factor, beta 1	Rattus norvegicus	126-135	
11707697-12	2001	This protective action of TGF-beta1 was abrogated by PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	53-60	transforming growth factor, beta 1	Rattus norvegicus	26-35	
11679965-7	2001	As assessed by radioactive labeling, transforming growth factor beta(1) (TGF-beta(1)) induced a time-dependent 2- to 15-fold increase in the de novo synthesis of RAGE protein, which was completely abolished using PD098059, a specific inhibitor of the mitogen-activated protein kinase (MAPK) kinase.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	213-221	transforming growth factor, beta 1	Rattus norvegicus	37-71	
11679965-7	2001	As assessed by radioactive labeling, transforming growth factor beta(1) (TGF-beta(1)) induced a time-dependent 2- to 15-fold increase in the de novo synthesis of RAGE protein, which was completely abolished using PD098059, a specific inhibitor of the mitogen-activated protein kinase (MAPK) kinase.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	213-221	transforming growth factor, beta 1	Rattus norvegicus	73-84	
11483646-3	2001	Cultured astrocytes lost the ability to produce transforming growth factor-beta1 (TGF-beta1) in response to mGlu2/3 receptor agonists when co-incubated with PD98059 or LY294002.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	157-164	transforming growth factor, beta 1	Rattus norvegicus	48-80	
11483646-3	2001	Cultured astrocytes lost the ability to produce transforming growth factor-beta1 (TGF-beta1) in response to mGlu2/3 receptor agonists when co-incubated with PD98059 or LY294002.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	157-164	transforming growth factor, beta 1	Rattus norvegicus	82-91	
11483646-6	2001	Similarly to that observed in the culture, intracerebral or systemic injections of mGlu2/3 receptor agonists enhanced TGF-beta1 formation in the rat or mouse caudate nucleus, and this effect was reduced by PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	206-213	transforming growth factor, beta 1	Rattus norvegicus	118-127	
10966845-9	2000	Further, DNA synthesis and transactivation of type II collagen by TGF beta were inhibited by PD98059, an inhibitor of MEK.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	93-100	transforming growth factor, beta 1	Rattus norvegicus	66-74	
10880840-8	2000	The PD098059 inhibitor decreased both IFN-gamma and TNF-alpha production and together with TGF-beta1, it totally blocked IFN-gamma, TNF-alpha and IL-10 production.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	4-12	transforming growth factor, beta 1	Rattus norvegicus	91-100	
10935498-8	1999	Also, PD98059, a specific inhibitor of MEK/ERK pathway, and SB203580, a specific inhibitor of p38 MAPK activity, significantly inhibited the induction of COX-2 in response to combined EGF and TGF-beta1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	6-13	transforming growth factor, beta 1	Rattus norvegicus	192-201	
10208426-8	1999	Either inactivation of Ras by stable, inducible expression of a dominant-negative mutant of Ras (RasN17) or addition of MAP and ERK kinase (MEK) inhibitor PD98059 to cells significantly decreased the ability of both TGFbeta and BMP to induce phosphorylation of endogenous Smad1 in IECs.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	155-162	transforming growth factor, beta 1	Rattus norvegicus	216-223	
10406835-6	1999	Treatment of VSMCs with PD98059, a specific inhibitor of the ERK pathway, attenuated both the activation of AP-1 and the increase in TGF-beta(1) mRNA induced by Ang II.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	24-31	transforming growth factor, beta 1	Rattus norvegicus	133-144	
10580747-8	1999	However, a specific MEK1 inhibitor, PD98059, significantly decreased TGF-beta1 induced Elk1 phosphorylation in a dose-dependent manner.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	36-43	transforming growth factor, beta 1	Rattus norvegicus	69-78	
10580747-9	1999	Furthermore, PD98059 reduced the TGF-beta1-induced cell growth by 40%.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	13-20	transforming growth factor, beta 1	Rattus norvegicus	33-42	
10208426-9	1999	Moreover, either inactivation of Ras or addition of PD98059 to IEC 4-1 cells inhibited the ability of RSmad1 to regulate 3TP luciferase activity in both the presence and absence of TGFbeta.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	52-59	transforming growth factor, beta 1	Rattus norvegicus	181-188	
26165845-7	2015	In addition, TGF-beta1-induced type II collagen and aggrecan expression were significantly suppressed by ERK1/2 inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	122-129	transforming growth factor, beta 1	Rattus norvegicus	13-22	
31729763-12	2020	Both MAPKs were upstream to p65/NF-kB inasmuch as both MAPKs" inhibitors PD98059 and SP600125 or their down-regulation by siRNA significantly blocked the TGF-beta1-induced nuclear translocation of p65/NF-kB.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	73-80	transforming growth factor, beta 1	Rattus norvegicus	154-163	
27025157-6	2016	In contrast, pretreatment with estrogen receptor inhibitor ICI182780 or ERK inhibitor PD98059 prevented the enhanced phosphorylation of ERK1/2, and subsequently inhibited the up-regulation of transforming growth factor-beta1 (TGF-beta1) expression induced by BPA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	86-93	transforming growth factor, beta 1	Rattus norvegicus	192-224	
27025157-6	2016	In contrast, pretreatment with estrogen receptor inhibitor ICI182780 or ERK inhibitor PD98059 prevented the enhanced phosphorylation of ERK1/2, and subsequently inhibited the up-regulation of transforming growth factor-beta1 (TGF-beta1) expression induced by BPA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	86-93	transforming growth factor, beta 1	Rattus norvegicus	226-235	
26075533-9	2015	Treatment with ERK1/2 inhibitors (PD98059 and U0126) abolished the antagonistic effect of TGF-beta1 on TNF-alpha mediated catabolic responses.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	34-41	transforming growth factor, beta 1	Rattus norvegicus	90-99	
25560488-2	2015	After DEN-induced hepatocellular carcinoma (HCC) in rats showed increased phosphorylation of JNK1/2, p38, and ERK1/2, we next antagonized TGF-beta1-induced phosphorylation of JNK1/2, p38, ERK1/2, Smad2/3 signaling in HepG2 cells using SP600125, SB203580, and PD98059, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	259-266	transforming growth factor, beta 1	Rattus norvegicus	138-147	
26136938-8	2015	Furthermore, the mRNA expression levels of TGF-beta1, BMP-2 and CBFalpha1 decreased in the quercetin + SP600125 (inhibitor of JNK) and quercetin + PD98059 (inhibitor of ERK1/2) groups.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	147-154	transforming growth factor, beta 1	Rattus norvegicus	43-52	
25231827-8	2015	Besides, laser-induced TGF-beta1 expression was significantly inhibited by extracellular signal-regulated kinase (ERK) specific inhibitor (PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	139-146	transforming growth factor, beta 1	Rattus norvegicus	23-32	
25592322-9	2015	TGF-beta1-induced eIF3a expression was reversed in the presence of PD98059, an inhibitor of ERK1/2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	67-74	transforming growth factor, beta 1	Rattus norvegicus	0-9	
25245272-5	2014	The results show PD98059 treatment significantly suppressed TGF-beta1-induced ERK1/2 phosphorylation and TIMP-3 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	17-24	transforming growth factor, beta 1	Rattus norvegicus	60-69	
25406076-11	2014	Further study showed that TGF-beta1 could induce phosphorylation of moesin which depended on Erk signaling pathway and Erk inhibitor PD98059 could block moesin phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	133-140	transforming growth factor, beta 1	Rattus norvegicus	26-35	
24001173-8	2014	PD98059, ERK siRNA and an anti-TGF-beta (transforming growth factor-beta) antibody abolished the SRF-binding activity enhanced by hypoxia or exogenous administration of TGF-beta.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	transforming growth factor, beta 1	Rattus norvegicus	169-177	
22764581-8	2012	AKF-PD, PD98059, and JNK inhibitor II completely prevented TGF-beta1-induced FN protein production.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	8-15	transforming growth factor, beta 1	Rattus norvegicus	59-68	
22521802-12	2012	Inhibition of ERK MAPK activation with PD98059 completely blocked the ability of TGF-beta/Smad3 to stimulate VSMC proliferation, demonstrating the importance of ERK MAPK in this pathway.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	39-46	transforming growth factor, beta 1	Rattus norvegicus	81-89	
22659623-8	2012	This result may be related to activation of the MR/ERK-Sp1 signalling pathway because PD98059, an ERK1/2 inhibitor, significantly blocked the rapid phosphorylation of ERK1/2 and function of Sp1 and led to reduced expression of TGFbeta1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	86-93	transforming growth factor, beta 1	Rattus norvegicus	227-235	
22764581-9	2012	In addition, AKF-PD, PD98059 and SB203580 greatly attenuated alpha-SMA expression induced by TGF-beta1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	21-28	transforming growth factor, beta 1	Rattus norvegicus	93-102	
21925118-10	2011	Moreover, SB431542, gefitinib, PD98059 (an ERK1/2 inhibitor), and SB203580 attenuated TGF-beta1-induced cell mitogenesis.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	31-38	transforming growth factor, beta 1	Rattus norvegicus	86-95	
22285838-9	2012	Treatment of cells with the specific MEK1 inhibitor PD98059 or U0126 suppressed ERK1/2 phosphorylation and TGF-beta1 expression, and completely restored the level of STAT3 (Tyr705) phosphorylation in MAPCs cultured in HG media.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	52-59	transforming growth factor, beta 1	Rattus norvegicus	107-116	
21367774-11	2011	The extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor PD98059 attenuated AngII-induced TGF-beta1 expression, Smad2/3 nuclear accumulation, and periostin expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	65-72	transforming growth factor, beta 1	Rattus norvegicus	98-107	
20466671-12	2010	Triptolide downregulated synthesis of fibronectin and collagen type III in TGF-beta1-stimulated cells treated with SB203580 and/or PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	131-138	transforming growth factor, beta 1	Rattus norvegicus	75-84	
20466671-13	2010	SB203580 and/or PD98059 significantly repressed synthesis of fibronectin and collagen type III in TGF-beta1-stimulated cells treated with triptolide.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	16-23	transforming growth factor, beta 1	Rattus norvegicus	98-107	
19960006-10	2009	The effects of high glucose on TGF-beta1 mRNA were markedly inhibited by suramin, DPI or PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	89-96	transforming growth factor, beta 1	Rattus norvegicus	31-40	
20432467-6	2010	When we treated cells with the Erk inhibitor, PD98059, it inhibited TGF-beta1-induced CTGF protein expression but had no effect on Src activation, Smad activation or Smad nuclear translocation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	46-53	transforming growth factor, beta 1	Rattus norvegicus	68-77	
20590658-7	2010	TGF-beta1-stimulated gene expression of chondrogenic regulators, Sox9, Runx2 and Ihh, was also affected by activity of PD98059 and SB203580, to different degrees.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	119-126	transforming growth factor, beta 1	Rattus norvegicus	0-9	
18314002-9	2008	To confirm the vital role of Erk, we used the Erk inhibitor (PD98059) to block its activation, demonstrating that it prevented TGF-beta1 activation of the CTGF promoter and up-regulation of CTGF expression in osteoblasts.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	61-68	transforming growth factor, beta 1	Rattus norvegicus	127-136	
19194552-9	2009	Pre-treatment of cells with ERK1/2 inhibitor, PD98059, or JNK inhibitor, SP600125 significantly inhibited aldosterone-induced ERK1/2 and JNK activity and subsequently TGF-beta(1) production, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	46-53	transforming growth factor, beta 1	Rattus norvegicus	167-178	
18234639-10	2008	The secretion of type I collagen and the expression of cyclin D1, CDK4 and TGF-beta1 mRNA in acetaldehyde-induced HSCs were markedly inhibited by 50 and 100 micromol/L PD98059, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	168-175	transforming growth factor, beta 1	Rattus norvegicus	75-84	
15622520-2	2005	Pharmacologic agents that target MEK (PD98059, U0126) or src family (PP1) kinases attenuated TGF-beta1-dependent PAI-1 transcription in R22 aortic smooth muscle cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	38-45	transforming growth factor, beta 1	Rattus norvegicus	93-102	
16371439-13	2006	IL-1beta activated ERK, and PD-98059, a MEK1 inhibitor, blocked IL-1beta enhancement of TGF-beta(1) expression and secretion by PSCs.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	28-36	transforming growth factor, beta 1	Rattus norvegicus	88-99	
19061498-9	2008	However, pretreatment with 10058-F4 (an inhibitor of c-Myc transcriptional activity) or PD98059 (an inhibitor of ERK1/2) suppressed c-Myc expression and ERK1/2 phosphorylation, and inhibited cell cycle promotion by TGFbeta1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	88-95	transforming growth factor, beta 1	Rattus norvegicus	215-223	
17650227-8	2007	The secretion of type I collagen and transforming growth factor-beta-1 mRNA expression of acetaldehyde-induced hepatic stellate cells were markedly inhibited by 50 and 100 micromol/L PD98059, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	183-190	transforming growth factor, beta 1	Rattus norvegicus	37-70	
16598747-9	2006	Preincubation of cells with 10 nM PD98059, an extracellular signal-regulated kinase (ERK)-dependent pathway inhibitor, attenuated IL-6-enhanced TGF-beta1 expression and secretion of PSCs.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	34-41	transforming growth factor, beta 1	Rattus norvegicus	144-153	
15622520-12	2005	PP1, PD98059, and U0126 also inhibited TGF-beta1-dependent cell motility at concentrations that significantly attenuated PAI-1 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	5-12	transforming growth factor, beta 1	Rattus norvegicus	39-48	
16029631-8	2005	Inhibition of Erk-1/2 activation by Mek kinase inhibitor PD98059 suppressed CTGF-mediated myofibroblasts proliferation and significantly down-regulated expression of alpha-SMA protein in cells pretreated by TGF-beta(1) (P < 0.05).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	57-64	transforming growth factor, beta 1	Rattus norvegicus	207-218	
15703462-9	2005	The effect of TGF-beta on PMC VEGF gene expression and protein synthesis was inhibited by PD98059 (a specific MAP kinase inhibitor) and chelerythrine (a specific protein kinase C inhibitor), but not cholera toxin (activator of cyclic AMP) or herbimycin A (inhibitor of protein tyrosine kinase).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	90-97	transforming growth factor, beta 1	Rattus norvegicus	14-22	
14575868-8	2003	Both PD98059 and GF109203X inhibited the ATP-stimulated TGF-beta 1 mRNA expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	5-12	transforming growth factor, beta 1	Rattus norvegicus	56-66	
12952860-8	2004	SB-203580 or PD-98059 also abolished the HG-stimulated expression of TGF-beta protein.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	13-21	transforming growth factor, beta 1	Rattus norvegicus	69-77	
12865256-6	2003	Inhibition of either pathway with PD-098059 or SB-203580 decreased production of TGF-beta1 and nitrate plus nitrite (NOx).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	34-43	transforming growth factor, beta 1	Rattus norvegicus	81-90	
12875981-9	2003	Inhibition of Erk-1/2 activation by Mek kinase inhibitor PD98059 restored TGF-beta1-mediated Smad-2/3 nuclear accumulation and myofibroblast activation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	57-64	transforming growth factor, beta 1	Rattus norvegicus	74-83