PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17697615-13	2007	Inhibitors specific for the JNK (SP600125), MEK (PD98059), and p38 MAPK (SB203580), abrogated HMGB1-induced TNF-alpha secretion.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	49-56	high mobility group box 1	Homo sapiens	94-99	
23628898-7	2013	One of the mechanisms underlying these activating effects of ICs on human endothelial cells involves cell signaling by high-mobility group box 1 protein (HMGB1)-RAGE axis, as these effects can be partially blocked by HMGB1 A-box, soluble RAGE (sRAGE), SB203580, PD98059, Bay 117082 (P<0.05) and co-treatment with these agents (P<0.05).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	262-269	high mobility group box 1	Homo sapiens	119-144	
23628898-7	2013	One of the mechanisms underlying these activating effects of ICs on human endothelial cells involves cell signaling by high-mobility group box 1 protein (HMGB1)-RAGE axis, as these effects can be partially blocked by HMGB1 A-box, soluble RAGE (sRAGE), SB203580, PD98059, Bay 117082 (P<0.05) and co-treatment with these agents (P<0.05).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	262-269	high mobility group box 1	Homo sapiens	154-159	
21116767-8	2011	A series of RAGE and HMGB1 co-immunoprecipitation experiments in the presence of SB203580 and PD98059 (p38 MAPK and ERK inhibitors, respectively) demonstrated that RAGE-p38 MAPK and RAGE-ERK pathway might underlie extracellular HMGB1-mediated neuronal apoptosis.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	94-101	high mobility group box 1	Homo sapiens	21-26	
19588230-7	2009	The HMGb1-induced increases of cell proliferation, cell migration, and wound closure were abolished by the MEK inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	121-128	high mobility group box 1	Homo sapiens	4-9	
32471717-6	2020	Similarly, inhibition for ERK (PD98059), NF-kappaB (BAY11-7082) and c-Jun (c-Jun peptide), respectively, also suppressed the HMGB1 cytoplasm translocation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	31-38	high mobility group box 1	Homo sapiens	125-130	
17135572-5	2007	Inhibitors specific for the JNK (SP600125) and MEK (PD98059), but not p38 MAPK (SB203580), abrogated H(2)O(2)-induced, active HMGB1 release.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	52-59	high mobility group box 1	Homo sapiens	126-131