PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30073566-6	2018	Inhibitors of NF-kappaB, ERK, and JNK (BAY117082, PD98059, and SP600125) significantly suppressed the expression of CXCL1 and CCL2 that were induced by LPS for 3 h. However, the p38 inhibitor, SB203580, had no obvious effect on expression levels of CXCL1 and CCL2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	50-57	C-C motif chemokine ligand 2	Homo sapiens	126-130	
30073566-6	2018	Inhibitors of NF-kappaB, ERK, and JNK (BAY117082, PD98059, and SP600125) significantly suppressed the expression of CXCL1 and CCL2 that were induced by LPS for 3 h. However, the p38 inhibitor, SB203580, had no obvious effect on expression levels of CXCL1 and CCL2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	50-57	C-C motif chemokine ligand 2	Homo sapiens	259-263	
27394658-7	2016	Furthermore, treatment the MEK1/2 kinase inhibitor PD98059 blocked increases in MCP-1 secretion and augmented Cry1Ac-induced ICOS-L upregulation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	51-58	C-C motif chemokine ligand 2	Homo sapiens	80-85	
25738264-10	2015	The effect of testosterone on the expression of IL-6 and MCP-1 is inhibited by PD98059 , an ERK1/2 inhibitor, and PDTC, an NF-kappaB inhibitor.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	79-86	C-C motif chemokine ligand 2	Homo sapiens	57-62	
25715004-7	2015	The latanoprost-induced release of IL-6, IL-8, and MCP-1 was attenuated by inhibitors of MAPK (PD98059, SB203580, or JNK inhibitor II) or NF-kappaB (IkappaB kinase 2 inhibitor) signaling pathways.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	95-102	C-C motif chemokine ligand 2	Homo sapiens	51-56	
19218821-6	2009	Pretreatment with the ERK1/2 inhibitor PD98059 and JNK inhibitor SP600125 attenuated MCP-1 production by CysLTs.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	39-46	C-C motif chemokine ligand 2	Homo sapiens	85-90	
26894024-10	2012	In cultured VSMCs, leptin increased MCP-1 production in a dose-dependent manner, and this stimulating effect of leptin on MCP-1 expression was reversed by the MAPK (MEK) inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	180-187	C-C motif chemokine ligand 2	Homo sapiens	36-41	
26894024-10	2012	In cultured VSMCs, leptin increased MCP-1 production in a dose-dependent manner, and this stimulating effect of leptin on MCP-1 expression was reversed by the MAPK (MEK) inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	180-187	C-C motif chemokine ligand 2	Homo sapiens	122-127	
22674286-11	2012	Thrombin-mediated CCL2 production was attenuated by the thrombin inhibitor PPACK, the protein kinase Cdelta (PKCdelta) inhibitor rottlerin, the c-Src inhibitor PP2, epidermal growth factor receptor (EGFR) inhibitor AG-1478, MEK inhibitors PD98059 and U0126, or AP-1 inhibitors curcumin and tanshinone IIA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	239-246	C-C motif chemokine ligand 2	Homo sapiens	18-22	
22561121-6	2012	SP600125, PD98059, and LY294002 inhibited the induction of at least CCL2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	10-17	C-C motif chemokine ligand 2	Homo sapiens	68-72	
19923143-5	2010	Inhibition of MAPK p42/p44 by PD98059 partially reduced HG and BK induction of IL-6, CCL-2 and TGF-beta, whereas inhibition of PKC by staurosporine partially reduced HG- but not BK-induced overexpression of these cytokines and that of VEGF.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	30-37	C-C motif chemokine ligand 2	Homo sapiens	85-90	
19923143-6	2010	Staurosporine and PD98059 synergistically reduced the effect of HG on IL-6, CCL-2 and TGF-beta expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	C-C motif chemokine ligand 2	Homo sapiens	76-81	
18656701-7	2008	Selective inhibitors of p38 MAPK (SB203580), JNK (SP600125) and ERK (PD98059) could suppress TNF-alpha-induced CCL2 and ICAM-1 expression, while only p38 MAPK and ERK inhibitors could suppress TNF-alpha-induced VCAM-1 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	69-76	C-C motif chemokine ligand 2	Homo sapiens	111-115	
18055523-8	2008	CT-1-mediated upregulation of ICAM-1 and MCP-1 was suppressed by PD-98059, SB-203580, LY-294002, and parthenolide.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	65-73	C-C motif chemokine ligand 2	Homo sapiens	41-46	
17460254-9	2007	The MMC-related IL-8 and MCP-1 expression was inhibited by both a p38 inhibitor (SB203580) and an ERK inhibitor (PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	113-120	C-C motif chemokine ligand 2	Homo sapiens	25-30	
17627770-9	2007	Selective inhibitors of p38 MAPK (SB203580), ERK (PD98059), and JNK (SP600125) could differentially inhibit the production of EGF, VEGF and CCL2, thereby suggesting a role for MAPKs in IL-31 functions.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	50-57	C-C motif chemokine ligand 2	Homo sapiens	140-144	
17424890-12	2007	PD98059 and curcunmin (AP-1 inhibitor) markedly suppressed the TNF-alpha-induced CCL2 expression, whereas the effect of SB203580 was less noted.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	C-C motif chemokine ligand 2	Homo sapiens	81-85	
15020650-7	2004	The induction of tissue factor activity by MCP-1 is blocked by PD98059, an inhibitor of p42/44 activation, but not by SB203580, a selective p38 inhibitor.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	63-70	C-C motif chemokine ligand 2	Homo sapiens	43-48	
11053056-6	2000	Furthermore, treatment with either PD098059, SB203580, or the JNK-AP-1 inhibitor curcumin diminished the expression of MCP-1 and stromelysin.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	35-43	C-C motif chemokine ligand 2	Homo sapiens	119-124	
12067898-8	2002	PD98059 prevented MCP-1-induced extracellular signal-regulated kinase activation and cell proliferation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	C-C motif chemokine ligand 2	Homo sapiens	18-23	
11549724-8	2001	Blocking either the ERK1/ERK2 or the p38 pathway (with PD98059 or SB203580, respectively) significantly inhibited Bz-ATP-induced MCP-1 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	55-62	C-C motif chemokine ligand 2	Homo sapiens	129-134	
12704652-6	2003	Inhibition of ERK1/2 activation by PD98059 blocked MCP-1 induction.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	35-42	C-C motif chemokine ligand 2	Homo sapiens	51-56	
12393099-6	2002	MCP-1 also induced secretion of matrix metalloproteinase (MMP)-2 which along with ERK activation was inhibited by PD098059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	114-122	C-C motif chemokine ligand 2	Homo sapiens	0-5	
10720473-5	2000	The MCP-1 mRNA expression by GA was completely inhibited by PD98059 and genistein that inhibit mitogen activated protein (MAP) kinase kinase and tyrosine kinase, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	60-67	C-C motif chemokine ligand 2	Homo sapiens	4-9	
10669634-8	2000	However, simultaneous blockade of the ERK1/2 and ROS pathways by using PD098059 combined with diphenylene iodonium or N-acetylcysteine potently enhanced the ability of MAPK kinase inhibitors to abrogate MCP-1 mRNA expression (100+/-2% inhibition).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	71-79	C-C motif chemokine ligand 2	Homo sapiens	203-208