PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28785074-7	2017	In addition, treatment of PD98059 reversed low-dose arsenite-induced MDM2 expression, and the inhibition of ERK2 expression could significantly block MDM2 expression as a consequence, and p53 expression automatically was increased.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	26-33	MDM2 proto-oncogene	Homo sapiens	69-73	
11761456-6	2001	Inhibition of cisplatin-induced ERK activity by PD98059 resulted in decreased levels of p21WAF1, Gadd45 and Mdm2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	48-55	MDM2 proto-oncogene	Homo sapiens	108-112	
21311676-8	2010	With the co-treatment of PD98059 and melatonin, the expression of p-p53, p21, and MDM2 did not decrease.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	25-32	MDM2 proto-oncogene	Homo sapiens	82-86	
17107963-4	2007	We found that growth factor-induced Ser-166 phosphorylation of Mdm2 was inhibited by the MEK inhibitors U0126 and PD98059 in HepG2 cells and in a rat liver cell line, TRL 1215.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	114-121	MDM2 proto-oncogene	Homo sapiens	63-67