PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15240011-6	2004	In accordance with these findings, BK-induced phosphorylation of p42/p44 MAPK and Akt and activation of NF-kappaB was attenuated by prior treatment with PD98059, LY294002, and helenalin, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	153-160	AKT serine/threonine kinase 1	Rattus norvegicus	82-85	
15922325-3	2005	Honokiol-induced neurite outgrowth in the cultured rat cortical neurons was significantly reduced by PD98059, a mitogen-activated protein kinase kinase (MAPKK, MAPK/ERK kinase MEK, direct upstream of ERK1/2) inhibitor, but not by LY294002, a phosphoinositide 3-kinase (PI3K, upstream of Akt) inhibitor.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	101-108	AKT serine/threonine kinase 1	Rattus norvegicus	287-290	
15834331-16	2005	Finally, inhibition of PI3K/Akt and MEK/ERK pathway using the inhibitors LY294002 and PD98059, respectively, impaired cell survival.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	86-93	AKT serine/threonine kinase 1	Rattus norvegicus	28-31	
15358610-6	2005	Inhibiting the IPC-induced phosphorylation of Akt, ERK-1/2, and p70S6K at reperfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002 or the MEK-1/2 inhibitor PD-98059 abrogated IPC-induced protection (46.3 +/- 5.8, 49.2 +/- 4.0, and 20.9 +/- 3.6% for IPC + LY-294002, IPC + PD-98059, and IPC, respectively, P < 0.01), demonstrating that the phosphorylation of these kinases at reperfusion is required for IPC-induced protection.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	177-185	AKT serine/threonine kinase 1	Rattus norvegicus	46-49	
17267947-6	2007	Wortmannin, LY294002, and PD98059, used as inhibitors of upstream kinases (the PI3-kinase/Akt/PDK1 or MEK-1 pathway) in cultures, markedly attenuated AA release and the expression of phosphorylated forms of endothelial cPLA(2), PKCalpha, and ERK1/2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	26-33	AKT serine/threonine kinase 1	Rattus norvegicus	90-93	
12850696-6	2003	However, this up-regulation of PI3K/Akt phosphorylation was markedly diminished following addition of GFX and PD-98059, inhibitors for protein kinase C (PKC) and ERK/MAPK, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Rattus norvegicus	36-39	
11502202-10	2001	PD098059 also inhibited the stimulation of Akt phosphorylation by HGF/SF and wortmannin similarly inhibited the stimulation of p42/44(MAPK) dual phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	43-46	
12753092-3	2003	The NGF-induced survival was completely blocked by either wortmannin (100 nM) or PD98059 (25-50 nM), which selectively inhibit the phosphatidylinositol 3-kinase-AKT (PI3 kinase-AKT) and mitogen-activated kinase kinase extracellular regulated kinase (MEK-ERKs) pathways, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	81-88	AKT serine/threonine kinase 1	Rattus norvegicus	161-164	
12753092-3	2003	The NGF-induced survival was completely blocked by either wortmannin (100 nM) or PD98059 (25-50 nM), which selectively inhibit the phosphatidylinositol 3-kinase-AKT (PI3 kinase-AKT) and mitogen-activated kinase kinase extracellular regulated kinase (MEK-ERKs) pathways, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	81-88	AKT serine/threonine kinase 1	Rattus norvegicus	177-180	
12753092-5	2003	In concordance with the survival assays, wortmannin and PD98059 blocked AKT and ERKs activation, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	56-63	AKT serine/threonine kinase 1	Rattus norvegicus	72-75	
10574325-3	1999	Insulin-stimulated triacylglycerol synthesis and insulin-stimulated protein kinase B/Akt activity were inhibited by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY 294002, and the mitogen-activated protein kinase kinase inhibitor PD 98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	245-253	AKT serine/threonine kinase 1	Rattus norvegicus	85-88	
33602886-9	2021	Furthermore, hypoxiaactivated extracellular signal-regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) were completely abolished by Src inhibitor 1 (1.0 microM), and hypoxia-increased GATA4 was inhibited by the ERK1/2 and Akt antagonists PD98059 (10.0 microM) and LY294002 (10.0 microM), respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	243-250	AKT serine/threonine kinase 1	Rattus norvegicus	103-106	
33738663-10	2021	Furthermore, CK activated MEK/ERK1/2 and PI3K/AKT pathways, and the beneficial effects of CK on primary Schwann cells and RSC96 cells were distinctly suppressed by inhibitor PD98059 or LY294002.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	174-181	AKT serine/threonine kinase 1	Rattus norvegicus	46-49	
35510038-11	2022	Mechanically, HG-enhanced ALP activity, AKT, and ERK phosphorylation were inhibited by LIRA, PI3K antagonist LY294002, or ERK1/2 antagonist PD98059, in which cotreatment of LIRA with LY294002 and PD98059 could further enhance the effect of LIRA on VSMC, and GLP-1R antagonists reversed the phenotypes in the model.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	140-147	AKT serine/threonine kinase 1	Rattus norvegicus	40-43	
33400052-13	2021	Abrogation of MEK/ERK- or phosphatidylinositol-3-kinase(PI3K)/Akt/GSK3beta-signaling with PD98059 or LY290042, respectively, inhibited hypertrophic growth under TAPI-0.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	90-97	AKT serine/threonine kinase 1	Rattus norvegicus	62-65	
27538649-10	2016	Compared with the I/R+Xe group, the I/R+PD98059+Xe and I/R+wortmannin+Xe groups showed worse neurological outcomes and less p-Akt and p-ERK at each time point (P<0.05).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	40-47	AKT serine/threonine kinase 1	Rattus norvegicus	126-129	
30134819-14	2018	For assessment of downstream signals, the PI3K inhibitor LY294002 and the MEK inhibitor PD98059 suppressed the phosphorylation of AKT and ERK1/2 respectively and abolished the cardioprotective effects induced by IP and NRG-1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	88-95	AKT serine/threonine kinase 1	Rattus norvegicus	130-133	
27085942-11	2016	The potential inhibitory effects downstream of the Akt and ERK signaling pathways were examined by administration of specific inhibitors LY294002 and PD98059 in vivo.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	150-157	AKT serine/threonine kinase 1	Rattus norvegicus	51-54	
27085942-16	2016	The administration of PI3K/Akt and MAPK/ERK signaling pathway specific inhibitors, LY294002 and PD98059, suppressed expression of both p-Akt and p-ERK.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	96-103	AKT serine/threonine kinase 1	Rattus norvegicus	27-30	
27085942-16	2016	The administration of PI3K/Akt and MAPK/ERK signaling pathway specific inhibitors, LY294002 and PD98059, suppressed expression of both p-Akt and p-ERK.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	96-103	AKT serine/threonine kinase 1	Rattus norvegicus	137-140	
26347199-9	2015	The employment of specific chemical inhibitors, SB203580, LY294002, PD98059, and AG490, demonstrated the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in the regulatory effect of UA on NOX4 activity and expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	68-75	AKT serine/threonine kinase 1	Rattus norvegicus	130-133	
27073387-8	2016	Consistent with this effect, Rg1 upregulated the phosphorylation of Akt and ERK1/2; these effects were reversed by API-2 and PD98059, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	125-132	AKT serine/threonine kinase 1	Rattus norvegicus	68-71	
26296503-7	2015	Pretreatment with wortmannin or PD98059 abrogated the protective effects of MPC and suppressed the phosphorylation of Akt, ERK and GSK-3beta.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	32-39	AKT serine/threonine kinase 1	Rattus norvegicus	118-121	
26099282-7	2015	To inhibit the PI3K/AKT and ERK1/2 pathway, LY294002 and PD98059 were used, respectively or in combination.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	57-64	AKT serine/threonine kinase 1	Rattus norvegicus	20-23	
25999679-15	2015	Pretreatment with PD98059 and LY294002 abolished TCS-401-induced activation of Erk, Akt, cell proliferation, and cell migration.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	AKT serine/threonine kinase 1	Rattus norvegicus	84-87	
25338292-12	2015	IPC2 x 5 min significantly upregulates the expressions of p-Akt and p-ERK1/2, which were inhibited by LY294002 or (and) PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	120-127	AKT serine/threonine kinase 1	Rattus norvegicus	60-63	
22490886-7	2012	The phosphorylation of Akt and PRAS40 induced by IGF-1 (100ng/ml) was inhibited by the phosphatidylinositide 3-kinase (PI3K) specific inhibitor LY294002 (50muM), while no inhibitory effect was observed for a MAPK kinase pathway specific inhibitor PD98059 nor a p38 MAPK inhibitor PD169316, suggesting that the phosphorylation of PRAS40 induced by IGF-1 is mediated by the PI3K pathway in PC12 cells and primary cultured neurons.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	247-254	AKT serine/threonine kinase 1	Rattus norvegicus	23-26	
25338292-5	2015	LY294002 or (and) PD98059 were injected intracerebroventricularly to selectively inhibit the activation of PI3K/Akt or ERK1/2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	AKT serine/threonine kinase 1	Rattus norvegicus	112-115	
25533999-6	2015	Inhibition of these PI3K/Akt and ERK1/2 pathways by specific inhibitors, LY294002 and PD98059, partially reduces the protective effect of bFGF.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	86-93	AKT serine/threonine kinase 1	Rattus norvegicus	25-28	
24995704-7	2014	Immunoblotting and immunohistochemical analysis showed that the microinjection of LY294002 (0.6 pmol) or PD98059 (3.0 pmol) into the NTS attenuated the IGF-1-induced depressor effects and Akt or ERK phosphorylation in WKY rats.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	105-112	AKT serine/threonine kinase 1	Rattus norvegicus	188-191	
24464033-6	2014	Moreover, the inhibition of the IPC-induced activation of Erk1/2 and Akt using PD98059 or wortmannin downregulated the ODC/polyamine system.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	79-86	AKT serine/threonine kinase 1	Rattus norvegicus	69-72	
24467537-10	2014	Pretreatment with a PI3K inhibitor wortmannin or an ERK1/2 inhibitor PD98059 not only blocked Akt and ERK1/2 phosphorylation respectively, but also inhibited the cardioprotective effects of SCE.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	69-76	AKT serine/threonine kinase 1	Rattus norvegicus	94-97	
23889671-9	2013	Likewise, administration of Akt and ERK1/2 signalling inhibitors, LY294002 and PD98059, attenuated the reduction in BP evoked by simvastatin.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	79-86	AKT serine/threonine kinase 1	Rattus norvegicus	28-31	
23460471-5	2013	Snail expression induced by PDGF-BB in MSCs is inhibited by LY294002 and PD98059, which are inhibitors of the PI3K/AKT and MAPK1/2/ERK1/2 signaling pathways, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	73-80	AKT serine/threonine kinase 1	Rattus norvegicus	115-118	
23219579-10	2013	The increasing expressions of p-Akt and p-ERK1/2 induced by Dex in the ischemic hemisphere were markedly inhibited by LY294002 (or wortmannin) and U0126 (or PD98059), respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	157-164	AKT serine/threonine kinase 1	Rattus norvegicus	32-35	
22674052-5	2013	Besides, expression of phosphorylated-AKT and phosphorylated-ERK1/2 in fluoxetine-treated NSCs was effectively blocked (P<0.05) by both PI3-K inhibitor (LY294002) and MEK inhibitor (PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	185-192	AKT serine/threonine kinase 1	Rattus norvegicus	38-41	
22575563-9	2012	PD98059 (an inhibitor of MEK 1/2) or SP600125 (an inhibitor of SAPK/JNK), which suppressed FGF-2-induced phosphorylation of p44/p42 MAP kinase or SAPK/JNK respectively, did not affect FGF-2-induced Akt phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	AKT serine/threonine kinase 1	Rattus norvegicus	198-201	
22147269-8	2012	Acteoside activated both ERK and PI3 K/Akt, and treatments with the specific ERK inhibitor PD98059, the PI3 K inhibitor LY294002, and the specific Nrf2 siRNA suppressed the acteoside-induced HO-1 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	91-98	AKT serine/threonine kinase 1	Rattus norvegicus	39-42	
22019741-6	2011	The phosphorylation of extracellular regulating protein kinase (Erk) and Akt can be induced by the administration of 50muM deprenyl in PC12 cells, and the ability of deprenyl to enhance NQO1 expression and Nrf2 nuclear translocation is partly attenuated by the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059 and is almost completely attenuated by the phosphatidyl-inositol 3 kinase (PI3K) inhibitor LY294002.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	317-324	AKT serine/threonine kinase 1	Rattus norvegicus	73-76	
21699895-5	2011	The phosphorylation of ERK1/2 and Akt in Schwann cells was blocked by the MEK inhibitor PD98059 and the PI3K inhibitor wortmannin.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	88-95	AKT serine/threonine kinase 1	Rattus norvegicus	34-37	
19235132-4	2009	Pretreatment for 15 min with 10 muM of PI3K/Akt inhibitor LY294002 or with 20 muM PD98059, inhibitor of ERK 1/2, significantly reduced INS-stimulated Akt and ERK 1/2 phosphorylation by 76 and 75%, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	82-89	AKT serine/threonine kinase 1	Rattus norvegicus	150-153	
19879250-7	2010	Studies using the specific MEK inhibitor, PD98059, revealed that ERK1/2 activation also mediates Ang II-induced S6K-1 and IRS-1 phosphorylation, and the impairment of Akt Thr(308) and GSK-3alpha/beta phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	42-49	AKT serine/threonine kinase 1	Rattus norvegicus	167-170	
20404059-8	2010	Whereas the treatment with LY-294002 decreased the phosphorylation of Akt only, the treatment with UO-126 decreased ERK1/2, and that with PD-98059 decreased both Akt and ERK1/2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	138-146	AKT serine/threonine kinase 1	Rattus norvegicus	162-165	
19318234-7	2009	ET-1-induced phosphorylation of GSK-3beta(Ser9) was attenuated by inhibitors of phosphatidylinositol 3-kinase (LY294002), Akt (Akt inhibitor VIII), ERK1/2 (PD98059) and by the AMPK agonist 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	156-163	AKT serine/threonine kinase 1	Rattus norvegicus	122-125	
18975057-7	2009	Physiological significance of these kinase activations was established by demonstrating that inhibition of Akt by LY294002 and ERK1/2 by PD98059 compromised the cardioprotective effect of all the substances studied.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	137-144	AKT serine/threonine kinase 1	Rattus norvegicus	107-110