PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22325981-4	2012	Recently, we demonstrated that the dopamine agonist pramipexole improves the therapeutic effect of L-dopa in 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency, the most common disorder of BH4 metabolism.	Pramipexole	52-63	6-pyruvoyltetrahydropterin synthase	Homo sapiens	147-151	
27562098-4	2016	To improve this picture, since 2009 we introduced the non-ergot dopamine agonist pramipexole as an adjunct to l-dopa therapy in the treatment of the most common causes of BH4 deficiency, 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency and dihydropteridine reductase (DHPR) deficiency.	Pramipexole	81-92	6-pyruvoyltetrahydropterin synthase	Homo sapiens	187-223	
27562098-4	2016	To improve this picture, since 2009 we introduced the non-ergot dopamine agonist pramipexole as an adjunct to l-dopa therapy in the treatment of the most common causes of BH4 deficiency, 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency and dihydropteridine reductase (DHPR) deficiency.	Pramipexole	81-92	6-pyruvoyltetrahydropterin synthase	Homo sapiens	225-229	
19704083-1	2009	OBJECTIVE: To report the efficacy, tolerability, and safety of the dopamine agonist pramipexole in a series of 5 patients affected by inherited 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency and needing l-3,4 dihydroxyphenylalanine (l-dopa) therapy.	Pramipexole	84-95	6-pyruvoyltetrahydropterin synthase	Homo sapiens	144-180	
19704083-1	2009	OBJECTIVE: To report the efficacy, tolerability, and safety of the dopamine agonist pramipexole in a series of 5 patients affected by inherited 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency and needing l-3,4 dihydroxyphenylalanine (l-dopa) therapy.	Pramipexole	84-95	6-pyruvoyltetrahydropterin synthase	Homo sapiens	182-186	
19704083-12	2009	CONCLUSIONS: The addition of pramipexole to the treatment of 6-pyruvoyl tetrahydropterin synthase deficiency improves the results of l-3,4 dihydroxyphenylalanine therapy.	Pramipexole	29-40	6-pyruvoyltetrahydropterin synthase	Homo sapiens	61-97