PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23850985-0 2013 Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. germacrone 44-54 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 70-85 23850985-1 2013 Misclassification of Curcuma species (family Zingiberaceae) may lead to unwanted human exposure to Curcuma elata sesquiterpenes zederone and germacrone which have caused hepatotoxicity and changes in CYP expression in laboratory animals. germacrone 141-151 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 200-203 23850985-6 2013 CYP inhibition studies with pooled human liver microsomes (HLMs) indicated that zederone and germacrone moderately inhibited CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 muM. germacrone 93-103 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3