PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23495258-4 2013 The results indicated that PEITC might be used as a potential therapeutic strategy to ADM resistance through blocking Akt and activating MAPK pathway in human bladder carcinoma. phenethyl isothiocyanate 27-32 AKT serine/threonine kinase 1 Homo sapiens 118-121 23956061-7 2014 PEITC may be useful as the therapeutic strategy for overcoming multi-drug resistance through suppressing the PI3K-Akt pathway in human gastric cancer. phenethyl isothiocyanate 0-5 AKT serine/threonine kinase 1 Homo sapiens 114-117 22952709-6 2012 Growth inhibitory effects of PEITC were mediated by inhibition of EGFR and AKT, which are known to be overexpressed in ovarian tumors. phenethyl isothiocyanate 29-34 AKT serine/threonine kinase 1 Homo sapiens 75-78 22952709-8 2012 In addition, PEITC treatment drastically reduced the phosphorylation of AKT which is downstream to EGFR and disrupted mTOR signaling. phenethyl isothiocyanate 13-18 AKT serine/threonine kinase 1 Homo sapiens 72-75 22952709-9 2012 PEITC treatment also inhibited the kinase activity of AKT as observed by the down regulation of p-GSK in OVCAR-3 and TOV-21G cells. phenethyl isothiocyanate 0-5 AKT serine/threonine kinase 1 Homo sapiens 54-57 29955247-3 2018 In the early phase, PEITC treatment elicited cells" morphological changes that comprise reduction in cell volume and modification of actin organization concomitantly with a rapid activation of the PI3K/Akt pathway. phenethyl isothiocyanate 20-25 AKT serine/threonine kinase 1 Homo sapiens 202-205 21472003-5 2011 Conversely, enforced activation of Akt by a constitutively active Akt construct markedly abrogated PEITC-mediated JNK activation, Mcl-1 downregulation, caspase activation, and apoptosis, and also interruption of the JNK pathway by pharmacological or genetically (e.g., siRNA) attenuated PEITC-induced apoptosis. phenethyl isothiocyanate 287-292 AKT serine/threonine kinase 1 Homo sapiens 66-69 21472003-6 2011 Finally, administration of PEITC markedly inhibited tumor growth and induced apoptosis in U937 xenograft model in association with inactivation of Akt, activation of JNK, as well as downregulation of Mcl-1. phenethyl isothiocyanate 27-32 AKT serine/threonine kinase 1 Homo sapiens 147-150 21472003-7 2011 Taken together, these findings represent a novel mechanism by which agents targeting Akt/JNK/Mcl-1 pathway potentiate PEITC lethality in transformed and primary human leukemia cells and inhibitory activity of tumor growth of U937 xenograft model. phenethyl isothiocyanate 118-123 AKT serine/threonine kinase 1 Homo sapiens 85-88 35368876-12 2022 PEITC also altered the protein expressions of protein kinase B (Akt), extracellular signal-regulated kinase (ERK), and NF-kappaB signaling pathways. phenethyl isothiocyanate 0-5 AKT serine/threonine kinase 1 Homo sapiens 64-67 35368876-13 2022 The inflammatory responses in human glioblastoma cells may be suppressed by PEITC through the phosphoinositide 3-kinase (PI3K)/Akt/NF-kappaB signaling pathway. phenethyl isothiocyanate 76-81 AKT serine/threonine kinase 1 Homo sapiens 127-130 21472003-0 2011 Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways. phenethyl isothiocyanate 0-24 AKT serine/threonine kinase 1 Homo sapiens 96-99 21472003-4 2011 Inhibition of PI3K/Akt by LY294002 significantly enhanced PEITC-induced apoptosis. phenethyl isothiocyanate 58-63 AKT serine/threonine kinase 1 Homo sapiens 19-22 21472003-5 2011 Conversely, enforced activation of Akt by a constitutively active Akt construct markedly abrogated PEITC-mediated JNK activation, Mcl-1 downregulation, caspase activation, and apoptosis, and also interruption of the JNK pathway by pharmacological or genetically (e.g., siRNA) attenuated PEITC-induced apoptosis. phenethyl isothiocyanate 99-104 AKT serine/threonine kinase 1 Homo sapiens 35-38 21472003-5 2011 Conversely, enforced activation of Akt by a constitutively active Akt construct markedly abrogated PEITC-mediated JNK activation, Mcl-1 downregulation, caspase activation, and apoptosis, and also interruption of the JNK pathway by pharmacological or genetically (e.g., siRNA) attenuated PEITC-induced apoptosis. phenethyl isothiocyanate 99-104 AKT serine/threonine kinase 1 Homo sapiens 66-69 21472003-5 2011 Conversely, enforced activation of Akt by a constitutively active Akt construct markedly abrogated PEITC-mediated JNK activation, Mcl-1 downregulation, caspase activation, and apoptosis, and also interruption of the JNK pathway by pharmacological or genetically (e.g., siRNA) attenuated PEITC-induced apoptosis. phenethyl isothiocyanate 287-292 AKT serine/threonine kinase 1 Homo sapiens 35-38 20863062-8 2010 PEITC also inhibited the activities of AKT, ERK, JNK and PKC. phenethyl isothiocyanate 0-5 AKT serine/threonine kinase 1 Homo sapiens 39-42 16299382-7 2006 Studying upstream signaling events, we found that the phosphorylations of IkappaBalpha and Akt (Ser473, Thr308) were significantly attenuated by the combination of PEITC and curcumin. phenethyl isothiocyanate 164-169 AKT serine/threonine kinase 1 Homo sapiens 91-94 16299382-11 2006 We conclude that the simultaneous targeting of EGFR, Akt and NF-kappaB signaling pathways by PEITC and curcumin could be the molecular targets by which PEITC and curcumin exert their additive inhibitory effects on cell proliferation and ultimately lead to programmed cell death of tumor cells. phenethyl isothiocyanate 93-98 AKT serine/threonine kinase 1 Homo sapiens 53-56 16299382-11 2006 We conclude that the simultaneous targeting of EGFR, Akt and NF-kappaB signaling pathways by PEITC and curcumin could be the molecular targets by which PEITC and curcumin exert their additive inhibitory effects on cell proliferation and ultimately lead to programmed cell death of tumor cells. phenethyl isothiocyanate 152-157 AKT serine/threonine kinase 1 Homo sapiens 53-56 35368876-0 2022 Phenethyl Isothiocyanate Suppresses the Proinflammatory Cytokines in Human Glioblastoma Cells through the PI3K/Akt/NF-kappaB Signaling Pathway In Vitro. phenethyl isothiocyanate 0-24 AKT serine/threonine kinase 1 Homo sapiens 111-114 26548747-0 2015 Phenethyl isothiocyanate potentiates anti-tumour effect of doxorubicin through Akt-dependent pathway. phenethyl isothiocyanate 0-24 AKT serine/threonine kinase 1 Homo sapiens 79-82