PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30259634-5	2018	Furthermore, a Western blot analysis revealed that DHM significantly reduced levels of phosphorylated c-Jun N-terminal kinase 1/2, but not those of extracellular signal-regulated kinase 1/2 and p38.	dihydromyricetin	51-54	mitogen-activated protein kinase 8	Homo sapiens	102-129	
31894675-5	2019	RESULTS: DHM concentration-dependently inhibited cell migration and invasion and downregulated matrix metalloprotein -2 (MMP-2) and phosphorylated JNK (pJNK) expression in MKN45 cells, followed by upregulation of E-cadherin and downregulation of Vimentin.	dihydromyricetin	9-12	mitogen-activated protein kinase 8	Homo sapiens	147-150	
31894675-6	2019	Co-treatment with DHM and JNK inhibitor SP600125 further suppressed MMP-2 expression and cell invasion in MKN45 cells, suggesting that DHM inhibited MKN45 cells metastasis through JNK/MMP-2 pathway.	dihydromyricetin	18-21	mitogen-activated protein kinase 8	Homo sapiens	180-183	
31894675-6	2019	Co-treatment with DHM and JNK inhibitor SP600125 further suppressed MMP-2 expression and cell invasion in MKN45 cells, suggesting that DHM inhibited MKN45 cells metastasis through JNK/MMP-2 pathway.	dihydromyricetin	135-138	mitogen-activated protein kinase 8	Homo sapiens	26-29	
31894675-6	2019	Co-treatment with DHM and JNK inhibitor SP600125 further suppressed MMP-2 expression and cell invasion in MKN45 cells, suggesting that DHM inhibited MKN45 cells metastasis through JNK/MMP-2 pathway.	dihydromyricetin	135-138	mitogen-activated protein kinase 8	Homo sapiens	180-183	
31770410-8	2019	In addition, the JNK/ERK pathway may be involved in DHM-mediated caspase-3 activation and GRASP65 downregulation.	dihydromyricetin	52-55	mitogen-activated protein kinase 8	Homo sapiens	17-20	
27539140-8	2017	Furthermore, treatment of cells with specific inhibitors of ERK and JNK or NAC significantly promoted the DHM-induced activation of caspase-9/-7/-3 and PARP cleavage and also sensitized the antitumorigenic effect of DHM on NSCLC cells.	dihydromyricetin	106-109	mitogen-activated protein kinase 8	Homo sapiens	68-71	
27539140-0	2017	Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer.	dihydromyricetin	82-98	mitogen-activated protein kinase 8	Homo sapiens	56-59	
27539140-7	2017	Moreover, treatment of A549 and H1975 cells with DHM induced increase of intracellular peroxide and sustained activation of extracellular signal-regulated kinase (ERK)1/2 and c-Jun N-terminal kinase (JNK)1/2, and the reactive oxygen species scavenger, N-acetylcysteine (NAC), reversed DHM-induced ERK and JNK activation.	dihydromyricetin	49-52	mitogen-activated protein kinase 8	Homo sapiens	200-203	
27539140-8	2017	Furthermore, treatment of cells with specific inhibitors of ERK and JNK or NAC significantly promoted the DHM-induced activation of caspase-9/-7/-3 and PARP cleavage and also sensitized the antitumorigenic effect of DHM on NSCLC cells.	dihydromyricetin	216-219	mitogen-activated protein kinase 8	Homo sapiens	68-71	
25110435-15	2014	Further investigation indicated that DHM markedly reduced the phosphorylation levels of p38, ERK1/2 and JNK in a concentration-dependent manner but had no impact on the total protein levels.	dihydromyricetin	37-40	mitogen-activated protein kinase 8	Homo sapiens	104-107