PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29152142-7 2017 Xanthohumol induced cell cycle arrest as well as apoptosis through the reduction of cell cycle regulatory proteins as well as an increase in pro-apoptotic markers (cleaved poly ADP ribose polymerase, cleaved caspase-3) and a decrease in anti-apoptotic markers (X-linked inhibitor of apoptosis and survivin). xanthohumol 0-11 poly(ADP-ribose) polymerase 1 Homo sapiens 172-198 28105237-6 2016 Furthermore, xanthohumol treatment (40 microM) induced SCC4 cell apoptosis, as indicated by the significant increase in activity and expression of caspase-3, caspase-8, caspase-9, PARP, p53 and AIF. xanthohumol 13-24 poly(ADP-ribose) polymerase 1 Homo sapiens 180-184 28105237-8 2016 Taken together, the results of the present study indicated that xanthohumol mediates growth suppression and apoptosis induction, which was mediated via the suppression of Bcl-2 and Mcl-1 and activation of PARP, p53 and AIF signaling pathways. xanthohumol 64-75 poly(ADP-ribose) polymerase 1 Homo sapiens 205-209