PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11342529-8	2001	Leptin-induced ROS generation, CPT-1 activation, ACC inhibition, and MCP-1 overproduction were found to be completely prevented by either genistein, a tyrosine kinase inhibitor, H-89, a protein kinase A (PKA) inhibitor, or tetradecylglycidate, a CPT-1 inhibitor.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	178-182	C-C motif chemokine ligand 2	Homo sapiens	69-74	
14747610-9	2004	Paradoxically, H-89 antagonized MCP-1-induced [(3)H]AA release and enhanced the inhibitory effect of submaximal concentrations of rolipram and 8-bromo-cAMP.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	15-19	C-C motif chemokine ligand 2	Homo sapiens	32-37	
12952251-8	2003	H-89, an inhibitor of PKA, was able to inhibit the decrease in eotaxin and MCP-1 protein release induced by forskolin.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	0-4	C-C motif chemokine ligand 2	Homo sapiens	75-80	
27098798-8	2016	PKA inhibitor H-89 markedly reduced the oxLDL-induced MCP-1 expression, but no further decrease was observed when H-89 was used in combination with L-4F (50 mug/ml) (P > 0.05).	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	14-18	C-C motif chemokine ligand 2	Homo sapiens	54-59	
24661543-9	2014	H89 (PKA inhibitor) and sc-514 (IKKbeta inhibitor) each blocked TSH-stimulated MCP-1 mRNA expression and protein release, suggesting PKA and IKKbeta participate in this pathway.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	0-3	C-C motif chemokine ligand 2	Homo sapiens	79-84	
8587246-8	1995	Inhibition study using protein kinase inhibitors revealed that MCP-1 mRNA expression induced by IL-1 beta and TNF-alpha was suppressed by the tyrosine kinase inhibitor genistein, not by the protein kinase C inhibitors staurosporine or H-7, or the protein kinase A inhibitor H-89, suggesting an important role of tyrosine kinase in the cytokine-induced MCP-1 gene expression.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	274-278	C-C motif chemokine ligand 2	Homo sapiens	63-68