PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32347294-0	2020	Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	15-18	ribosomal protein S6 kinase B1	Homo sapiens	50-54	
32347294-6	2020	Here, we report that H89 (N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide), a well-characterized ATP-mimetic kinase inhibitor, renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors across multiple cell lines.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	21-24	ribosomal protein S6 kinase B1	Homo sapiens	170-174	
32347294-6	2020	Here, we report that H89 (N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide), a well-characterized ATP-mimetic kinase inhibitor, renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors across multiple cell lines.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	26-85	ribosomal protein S6 kinase B1	Homo sapiens	170-174	
32347294-7	2020	Moreover, H89 prevented the dephosphorylation of AKT and S6K1 under nutrient depleted conditions.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	10-13	ribosomal protein S6 kinase B1	Homo sapiens	57-61	
25486532-4	2014	The polyploidization was partially blocked by H-89, a cAMP-dependent protein kinase (PKA) inhibitor, through direct binding to S6K1, leading to dephosphorylation at Thr421/Ser424 and phosphorylation at Thr389, independent of PKA.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	46-50	ribosomal protein S6 kinase B1	Homo sapiens	127-131	
27667455-8	2016	H-89 not only blocked polyploidization, but also decreased the phosphorylation of S6K1 at Thr421/Ser424 and increased the phosphorylation of S6K1 at Thr389.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	0-4	ribosomal protein S6 kinase B1	Homo sapiens	82-86	
27667455-8	2016	H-89 not only blocked polyploidization, but also decreased the phosphorylation of S6K1 at Thr421/Ser424 and increased the phosphorylation of S6K1 at Thr389.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	0-4	ribosomal protein S6 kinase B1	Homo sapiens	141-145