PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17340013-2 2007 Here, we report the synthesis of triazole-containing analogues of the naturally occurring tyrosinase inhibitor cyclo-[Pro-Val-Pro-Tyr] and show that the analogues retain enzyme inhibitory activity, demonstrating the effectiveness of a 1,4-connected 1,2,3-triazole as a trans peptide bond isostere. Triazoles 33-41 tyrosinase Homo sapiens 90-100 26422245-7 2015 In addition, two benzene rings connecting to the triazole ring would produce larger steric hindrance, and affect the bonding between tyrosinase and inhibitors to decrease the inhibitory effects. Triazoles 49-57 tyrosinase Homo sapiens 133-143