PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33387581-3	2021	In this review, we discussed the antioxidant potential of chalcones and elucidated the mechanisms of pathways and proteins such as carbohydrate digestive enzymes (alpha-amylase and alpha-glucosidase), aldose reductase, SLGT-2, and Nrf2 that are targeted by antidiabetic chalcones.	Chalcones	58-67	sucrase-isomaltase	Homo sapiens	181-198	
31808389-1	2021	BACKGROUND: Chalcones, originated from natural product, have been broadly studied their biological activity against various proteins which at the molecular level, are responsible for the progress of the diseases in cancer (e.g. kinases), inflammation (oxidoreductases), atherosclerosis (cathepsins receptor), and diabetes (e.g. alpha-glucosidase).	Chalcones	12-21	sucrase-isomaltase	Homo sapiens	328-345	
28242551-0	2017	Analogues of xanthones--Chalcones and bis-chalcones as alpha-glucosidase inhibitors and anti-diabetes candidates.	Chalcones	24-33	sucrase-isomaltase	Homo sapiens	55-72	
31414099-3	2019	In the present work, a panel of chalcones bearing hydroxy, methoxy, methyl, nitro, chloro, fluoro and bromo substituents were evaluated against alpha-amylase and alpha-glucosidase activities, most of them for the first time.	Chalcones	32-41	sucrase-isomaltase	Homo sapiens	162-179	
31414099-6	2019	Chalcones holding nitro groups and chloro substituents, together with a hydroxy group in the chalcone scaffold, showed strong inhibition of the alpha-glucosidase activity.	Chalcones	0-9	sucrase-isomaltase	Homo sapiens	144-161	
25638569-3	2015	Several natural and (semi) synthetic chalcones deserve the credit of being potential candidates that act by modulating the therapeutic targets PPAR-gamma, DPP-4, alpha-glucosidase, PTP1B, aldose reductase, and stimulate insulin secretion and tissue sensitivity.	Chalcones	37-46	sucrase-isomaltase	Homo sapiens	162-179	
26351039-0	2015	Synthesis, alpha-glucosidase inhibitory and molecular docking studies of prenylated and geranylated flavones, isoflavones and chalcones.	Chalcones	126-135	sucrase-isomaltase	Homo sapiens	11-28	
16202584-3	2005	In particular, sulfonamide chalcones 17-20 had more potent alpha-glucosidase inhibitory activity than aminated chalcone 13-16.	Chalcones	27-36	sucrase-isomaltase	Homo sapiens	59-76	
17191997-2	2005	Both the benzothiazepines and chalcones were evaluated as DPPH free-radical scavengers and as inhibitors of cholinesterases, urease, and alpha-glucosidase.	Chalcones	30-39	sucrase-isomaltase	Homo sapiens	137-154