PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33743158-0	2021	Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders.	Chalcones	23-32	beta-secretase 1	Homo sapiens	66-72	
32890999-3	2020	In this work, we prepared a series of chalcones and 2"-aminochalcones, which were tested against AChE and BACE-1 enzymes and on the aggregation of Abeta.	Chalcones	38-47	beta-secretase 1	Homo sapiens	106-112	
32890999-5	2020	We have found that the majority of chalcones having the amino group are able to inhibit BACE-1, which was not observed for chalcones without this group.	Chalcones	35-44	beta-secretase 1	Homo sapiens	88-94	
32890999-5	2020	We have found that the majority of chalcones having the amino group are able to inhibit BACE-1, which was not observed for chalcones without this group.	Chalcones	123-132	beta-secretase 1	Homo sapiens	88-94	
30567381-2	2018	Although moderate inhibitory effect was observed for the chalcones against AChE, derivatives 2h, 2j and 2n exhibited significant inhibitory effect against BChE and BACE-1.	Chalcones	57-66	beta-secretase 1	Homo sapiens	164-170	
32867308-0	2020	Synthesis, In Silico and In Vitro Evaluation for Acetylcholinesterase and BACE-1 Inhibitory Activity of Some N-Substituted-4-Phenothiazine-Chalcones.	Chalcones	139-148	beta-secretase 1	Homo sapiens	74-80	
32867308-2	2020	Chalcones are the flavonoid derivatives with diverse bioactivities, including AChE and BACE-1 inhibition.	Chalcones	0-9	beta-secretase 1	Homo sapiens	87-93