PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31187716-5	2019	Hence, the present review highlights the significance of chalcones towardtheir CNS activities (up to 2019), which include anti-depressant activity, anxiolytic activity, activitywith GABA receptors, acetylcholinesterase (AChE) and butyryl cholinesterase (BChE) inhibitions, activityas adenosine receptor antagonists anti-Alzheimer"s agents, beta-amyloid plaques imaging agents,monoamine oxidase inhibition.	Chalcones	57-66	butyrylcholinesterase	Homo sapiens	230-252	
32924264-1	2020	Chalcones are considered effective templates for the development of monoamine oxidase (MAO) and cholinesterase (ChE) inhibitors.	Chalcones	0-9	butyrylcholinesterase	Homo sapiens	96-110	
32924264-1	2020	Chalcones are considered effective templates for the development of monoamine oxidase (MAO) and cholinesterase (ChE) inhibitors.	Chalcones	0-9	butyrylcholinesterase	Homo sapiens	112-115	
32924264-2	2020	The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Chalcones	81-90	butyrylcholinesterase	Homo sapiens	199-220	
32924264-2	2020	The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Chalcones	81-90	butyrylcholinesterase	Homo sapiens	222-226	
15895683-0	2005	Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones.	Chalcones	133-142	butyrylcholinesterase	Homo sapiens	65-103	
15895683-2	2005	It was observed that some of these compounds have the potential to inhibit acetylcholinesterase, whereas others show activity against butyrylcholinesterase, depending on the substitution pattern at the two aromatic rings of these chalcones.	Chalcones	230-239	butyrylcholinesterase	Homo sapiens	134-155	
31808389-0	2021	Anti-Cholinesterase Activity of Chalcone Derivatives: Synthesis, In Vitro Assay and Molecular Docking Study.	Chalcones	32-40	butyrylcholinesterase	Homo sapiens	5-19	
31808389-2	2021	OBJECTIVE: Here we synthesize 10 chalcone derivatives to be evaluated their in vitro enzymatic inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	Chalcones	33-41	butyrylcholinesterase	Homo sapiens	155-176	
31808389-2	2021	OBJECTIVE: Here we synthesize 10 chalcone derivatives to be evaluated their in vitro enzymatic inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	Chalcones	33-41	butyrylcholinesterase	Homo sapiens	178-182	
31808389-5	2021	Molecular docking studies predicted that this activity might be due to the interaction of the chalcones with important amino acid residues in the binding site of AChE such as SER200 and in that of BChE such as TRP82, SER198, TRP430, TYR440, LEU286 and VAL288.	Chalcones	94-103	butyrylcholinesterase	Homo sapiens	197-201	
31808389-6	2021	CONCLUSION: Chalcone can be used as the scaffold for cholinesterase inhibitor, in particularly either fluorine or nitro group to be augmented at the para-position of Ring B, whereas the hydrophobic chain is necessary at the meta-position of Ring B.	Chalcones	12-20	butyrylcholinesterase	Homo sapiens	53-67	
31187716-5	2019	Hence, the present review highlights the significance of chalcones towardtheir CNS activities (up to 2019), which include anti-depressant activity, anxiolytic activity, activitywith GABA receptors, acetylcholinesterase (AChE) and butyryl cholinesterase (BChE) inhibitions, activityas adenosine receptor antagonists anti-Alzheimer"s agents, beta-amyloid plaques imaging agents,monoamine oxidase inhibition.	Chalcones	57-66	butyrylcholinesterase	Homo sapiens	254-258	
26248214-0	2015	Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones.	Chalcones	123-132	butyrylcholinesterase	Homo sapiens	85-99	
30567381-2	2018	Although moderate inhibitory effect was observed for the chalcones against AChE, derivatives 2h, 2j and 2n exhibited significant inhibitory effect against BChE and BACE-1.	Chalcones	57-66	butyrylcholinesterase	Homo sapiens	155-159	
28687725-2	2017	In the present study, we intended to explore the cholinesterase inhibitory activity of some novel synthesized chalcones, together with their effect on beta-amyloid anti-aggregation.	Chalcones	110-119	butyrylcholinesterase	Homo sapiens	49-63	
26248214-3	2015	This work presents the design, synthesis, and biochemical evaluation of a series of chalcones, and assesses the relationship between their structures and their ability to bind metal ions and/or Abeta species, and inhibit AChE/BChE activity.	Chalcones	84-93	butyrylcholinesterase	Homo sapiens	226-230