PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26475964-9	2015	Furthermore, a correlation between the distinct cytotoxicity of chalcones 1 and 2 and their ability to disrupt the p53-MDM2 interaction was established.	Chalcones	64-73	tumor protein p53	Homo sapiens	115-118	
31117836-0	2019	Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells.	Chalcones	59-68	tumor protein p53	Homo sapiens	31-34	
15720190-10	2005	Small molecules that have been reported to disrupt the p53-MDM2 binding, thereby enhancing p53 activity to elicit anticancer effects include the following: synthetic chalcones, norbornane derivatives, cis-imidazoline derivatives (Nutlins), a pyrazolidinedione sulfonamide and 1,4-benzodiazepine-2,5-diones, as well as tryptophan derivatives.	Chalcones	166-175	tumor protein p53	Homo sapiens	91-94	
11148027-5	2001	Here, we show by multidimensional NMR spectroscopy that chalcones (1,3-diphenyl-2-propen-1-ones) are MDM2 inhibitors that bind to a subsite of the p53 binding cleft of human MDM2.	Chalcones	56-65	tumor protein p53	Homo sapiens	147-150	
30235848-15	2018	These effects probably result from the induced increase of p53 protein expression by the two chalcones.	Chalcones	93-102	tumor protein p53	Homo sapiens	59-62	
30235848-16	2018	In conclusion, chalcones D14 and D15 have potential anti-metastatic activity mediated by p53 that can be exploited for OS treatment.	Chalcones	15-24	tumor protein p53	Homo sapiens	89-92	
28743509-8	2017	Such activities were absent in 3-(4-methoxyphenyl)propiophenone (SSE14106H2) demonstrating the importance of conjugated ketone for antiproliferative and p53 stabilizing activity of the chalcones.	Chalcones	185-194	tumor protein p53	Homo sapiens	153-156	
28743509-10	2017	These chalcones can, therefore, act as fragment leads for further structure optimization to obtain more potent p53 stabilizing agents with enhanced anti-proliferative activities.	Chalcones	6-15	tumor protein p53	Homo sapiens	111-114	
26475964-10	2015	SIGNIFICANCE: This work shows that prenylation is a determinant factor for the enhancement of chalcones tumour cytotoxicity by improving their ability to disrupt the p53-MDM2 interaction.	Chalcones	94-103	tumor protein p53	Homo sapiens	166-169	
19275612-3	2009	Immunoblot assay showed that chalcones significantly decreased the expression of cyclin Bl, cyclin A and Cdc2 protein, as well as increased the expression of p21 and p27 in a p53-independent manner, contributing to cell cycle arrest.	Chalcones	29-38	tumor protein p53	Homo sapiens	175-178	
24467530-4	2014	These pathways and targets that are affected by chalcones include MDM2/p53, tubulin, proteasome, NF-kappa B, TRIAL/death receptors and mitochondria mediated apoptotic pathways, cell cycle, STAT3, AP-1, NRF2, AR, ER, PPAR-gamma and beta-catenin/Wnt.	Chalcones	48-57	tumor protein p53	Homo sapiens	71-74