PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29332599-0	2018	The Synthesis of Chalcones as Anticancer Prodrugs and their Bioactivation in CYP1 Expressing Breast Cancer Cells.	Chalcones	17-26	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	77-81	
29332599-9	2018	CONCLUSION: Chalcones show promise as anticancer agents with evidence suggesting that CYP1 activation of these compounds may be involved.	Chalcones	12-21	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	86-90	
29138024-3	2017	Herein, thirteen pyridine-4-yl series of chalcones were synthesized and screened for inhibition of CYP1 isoforms 1A1, 1B1 and 1A2 in Sacchrosomes  and live human HEK293 cells.	Chalcones	41-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	99-103	
29138024-4	2017	The structure-activity relationship analysis indicated that chalcones bearing tri-alkoxy groups (8a and 8k) on non-heterocyclic ring displayed selective inhibition of CYP1A1 enzyme, with IC50 values of 58 and 65 nM, respectively.	Chalcones	60-69	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	167-173	
28711350-2	2017	In this letter, we report synthesis of twenty-three pyrrole based heterocyclic chalcones which were screened for inhibition of CYP1 isoforms.	Chalcones	79-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	127-131	
28222316-1	2017	The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones.	Chalcones	109-118	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	66-72