PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28971779-6	2018	OBJECTIVE: Owing to high anticancer potential of ferrocene derivatives and considerable COX-2 inhibitory and cytotoxicity effects of our previously synthesized chalcones, we decided to incorporate the ferrocenyl moiety into appropriate COX-2 inhibitor chalcone based scaffold, to evaluate COX-2 inhibitory activity as well as anticancer activities.	Chalcones	160-169	prostaglandin-endoperoxide synthase 2	Homo sapiens	88-93	
28971779-6	2018	OBJECTIVE: Owing to high anticancer potential of ferrocene derivatives and considerable COX-2 inhibitory and cytotoxicity effects of our previously synthesized chalcones, we decided to incorporate the ferrocenyl moiety into appropriate COX-2 inhibitor chalcone based scaffold, to evaluate COX-2 inhibitory activity as well as anticancer activities.	Chalcones	160-169	prostaglandin-endoperoxide synthase 2	Homo sapiens	236-241	
28971779-6	2018	OBJECTIVE: Owing to high anticancer potential of ferrocene derivatives and considerable COX-2 inhibitory and cytotoxicity effects of our previously synthesized chalcones, we decided to incorporate the ferrocenyl moiety into appropriate COX-2 inhibitor chalcone based scaffold, to evaluate COX-2 inhibitory activity as well as anticancer activities.	Chalcones	160-169	prostaglandin-endoperoxide synthase 2	Homo sapiens	236-241	
20005707-1	2010	A novel series of nitrogen-containing chalcones were synthesized by Mannich reaction and were screened for anti-inflammatory related activities such as inhibition of cyclooxygenase-2 (COX-2), trypsin and beta-glucuronidase.	Chalcones	38-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	166-182	
20005707-1	2010	A novel series of nitrogen-containing chalcones were synthesized by Mannich reaction and were screened for anti-inflammatory related activities such as inhibition of cyclooxygenase-2 (COX-2), trypsin and beta-glucuronidase.	Chalcones	38-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	184-189	
20005707-5	2010	Whereas the chalcones with piperidine methyl substitution (8b, 7b, 7c, 6c, 4b, 3c, 3b) were observed as effective inhibitors of COX-2, while the same compounds were found to be less reactive against COX-1 as compared to COX-2.	Chalcones	12-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	128-133	
20005707-5	2010	Whereas the chalcones with piperidine methyl substitution (8b, 7b, 7c, 6c, 4b, 3c, 3b) were observed as effective inhibitors of COX-2, while the same compounds were found to be less reactive against COX-1 as compared to COX-2.	Chalcones	12-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	220-225