PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29860891-7 2019 The chalcones were effective inhibitors of the cytosolic CA isoforms (hCA I and hCA II) and AChE with Ki values in the range of 1.83-7.05 muM for hCA I, 0.59-5.50 muM for hCA II, and 0.61-86.11 muM for AChE. Chalcones 4-13 carbonic anhydrase 2 Homo sapiens 80-86 23360090-1 2013 New imines, derived from aromatic aldehyde, chalcones and 5-amino-1,3,4-thiadiazole-2-thiol exhibited promising anti-convulsant activity which is explained through chemo-biological interactions at receptor site producing the inhibition of human Carbonic Anhydrase-II enzyme (hCA-II) through the proposed pharmacophore model at molecular levels as basis for pharmacological activity. Chalcones 44-53 carbonic anhydrase 2 Homo sapiens 245-266 23360090-1 2013 New imines, derived from aromatic aldehyde, chalcones and 5-amino-1,3,4-thiadiazole-2-thiol exhibited promising anti-convulsant activity which is explained through chemo-biological interactions at receptor site producing the inhibition of human Carbonic Anhydrase-II enzyme (hCA-II) through the proposed pharmacophore model at molecular levels as basis for pharmacological activity. Chalcones 44-53 carbonic anhydrase 2 Homo sapiens 275-281