PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24583196-7 2014 Chalcones R7 and R13 induced an increase of pro-apoptotic proteins Bax, Bid and Bak (only chalcone R13), as well as a decrease in anti-apoptotic Bcl-2 expression. Chalcones 0-9 B cell leukemia/lymphoma 2 Mus musculus 145-150 27903423-7 2017 In western blot assay, the two chalcones reduced the expression of cell death-related proteins such as Bcl-2 and cyclin D1 and promoted the cleavage of PARP. Chalcones 31-40 B cell leukemia/lymphoma 2 Mus musculus 103-108 11055382-11 2000 From these results, it seems that the pathway by which the chalcones induce apoptosis may be independent of p53 and dependent on proteins of the Bcl-2 family. Chalcones 59-68 B cell leukemia/lymphoma 2 Mus musculus 145-150