PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33244799-0	2021	Design, synthesis, biological evaluation, and docking studies of some novel chalcones as selective COX-2 inhibitors.	Chalcones	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104	
33244799-1	2021	A new series of chalcones (1-9) possessing an SO2 CH3 COX-2 pharmacophore at the para position of the C-1 phenyl ring was synthesized via the Claisen-Schmidt condensation reaction and examined for their inhibition potential against cyclooxygenase (COX) enzymes.	Chalcones	16-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-59	
25276196-2	2014	In this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having different COX-1 and/or COX-2 selectivities have been examined on human hepatocarcinoma (HepG2), lung carcinoma (A549), and breast adenocarcinoma (MCF-7) cell line, using Sulforhodamine B (SRB) assay.	Chalcones	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141	
21714592-5	2011	The classification in this review includes COX-2 inhibitors based on five- and six-membered heterocycles, benzoheterocycles (e.g., benzopyrans, benzopyranones, indoles and quinolines), quinones, chalcones, natural products and miscellaneous.	Chalcones	195-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48	
16798002-1	2006	A group of (E)-1,3-diphenylprop-2-en-1-one derivatives (chalcones) possessing a MeSO(2)NH, or N(3), COX-2 pharmacophore at the para-position of the C-1 phenyl ring were synthesized using a facile stereoselective Claisen-Schmidt condensation reaction.	Chalcones	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105	
35208952-0	2022	EGFR and COX-2 Dual Inhibitor: The Design, Synthesis, and Biological Evaluation of Novel Chalcones.	Chalcones	89-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14	
12794878-4	2003	CAD of the metal complexes, especially [Co(II) (chalcone-H) 2,2"-bipyridine](+), allowed the most effective differentiation of the isomeric chalcones with several diagnostic fragment ions appearing upon activation of the metal complexes.	Chalcones	140-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46	
10814343-1	2000	[reaction: see text] Reactions of chalcones 3a-f with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5a-f, which resemble closely some previously prepared COX-2 inhibitors.	Chalcones	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191