PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27622714-7 2016 In contrast, in functional p53-impaired cells, this phytochemical exploits p53-paralogue p73, which up-regulates FAS to cleave BID through FAS-FADD-caspase-8-pathway. ammonium ferrous sulfate 113-116 tumor protein p53 Homo sapiens 27-30 31078603-6 2019 Furthermore, exposure to the Fe(II) complex led to excessive reactive oxygen species (ROS) accumulation by thioredoxin reductase (TrxR) inhibition and DNA double-strand breaks (DSBs), which in turn sequentially activated ATM, CHK1/2 and p53. ammonium ferrous sulfate 29-35 tumor protein p53 Homo sapiens 237-240 30591679-8 2018 RNA sequencing analysis suggested that sFRP4-mediated apoptosis is via the Fas-p53 pathway by activating the Wnt calcium and reactive oxygen species pathways. ammonium ferrous sulfate 75-78 tumor protein p53 Homo sapiens 79-82 29599323-10 2018 In addition, p53 was shown to be involved in gallic acid-mediated Fas, FasL, and DR5 expression as well as cell apoptosis in AGS cells. ammonium ferrous sulfate 66-69 tumor protein p53 Homo sapiens 13-16 28233940-5 2017 The iron(II) complex activated p53-mediated mitochondrial dysfunction as can be seen by the upregulation in the expression of p53 and proapoptotic Bcl-2 family proteins, and downregulation in the expression of Bcl-2 family proteins. ammonium ferrous sulfate 4-12 tumor protein p53 Homo sapiens 31-34 28233940-5 2017 The iron(II) complex activated p53-mediated mitochondrial dysfunction as can be seen by the upregulation in the expression of p53 and proapoptotic Bcl-2 family proteins, and downregulation in the expression of Bcl-2 family proteins. ammonium ferrous sulfate 4-12 tumor protein p53 Homo sapiens 126-129 27622714-7 2016 In contrast, in functional p53-impaired cells, this phytochemical exploits p53-paralogue p73, which up-regulates FAS to cleave BID through FAS-FADD-caspase-8-pathway. ammonium ferrous sulfate 113-116 tumor protein p53 Homo sapiens 75-78 27185843-10 2016 FAS and p53 were shown to be prognostic factors for PFS (7.0 months if FAS+ and p53-; 3.4 months if FAS+/p53+ or FAS-/p53-; and 0.7 months if FAS- and p53+; P < .001) and for overall survival. ammonium ferrous sulfate 71-74 tumor protein p53 Homo sapiens 8-11 26556860-6 2015 Loss of nucleolin can activate Fas-mediated apoptosis, leading to the increase of pro-apoptotic proteins (BID, fas-associated factor-2) and subsequent apoptosis of p53-negative, 2-FaraA refractory CLL cells. ammonium ferrous sulfate 31-34 tumor protein p53 Homo sapiens 164-167 26342440-6 2015 The hydrophilic Fe(II) complex entered cancer cells through transferring receptor (TfR)-mediated endocytosis, and translocated to cell nucleus, where they induced S phase cell cycle arrest through triggering DNA damage-mediated p53 pathway. ammonium ferrous sulfate 16-22 tumor protein p53 Homo sapiens 228-231 27185843-10 2016 FAS and p53 were shown to be prognostic factors for PFS (7.0 months if FAS+ and p53-; 3.4 months if FAS+/p53+ or FAS-/p53-; and 0.7 months if FAS- and p53+; P < .001) and for overall survival. ammonium ferrous sulfate 0-3 tumor protein p53 Homo sapiens 80-83 27185843-10 2016 FAS and p53 were shown to be prognostic factors for PFS (7.0 months if FAS+ and p53-; 3.4 months if FAS+/p53+ or FAS-/p53-; and 0.7 months if FAS- and p53+; P < .001) and for overall survival. ammonium ferrous sulfate 0-3 tumor protein p53 Homo sapiens 80-83 27185843-10 2016 FAS and p53 were shown to be prognostic factors for PFS (7.0 months if FAS+ and p53-; 3.4 months if FAS+/p53+ or FAS-/p53-; and 0.7 months if FAS- and p53+; P < .001) and for overall survival. ammonium ferrous sulfate 0-3 tumor protein p53 Homo sapiens 80-83 27185843-10 2016 FAS and p53 were shown to be prognostic factors for PFS (7.0 months if FAS+ and p53-; 3.4 months if FAS+/p53+ or FAS-/p53-; and 0.7 months if FAS- and p53+; P < .001) and for overall survival. ammonium ferrous sulfate 0-3 tumor protein p53 Homo sapiens 80-83 27185843-10 2016 FAS and p53 were shown to be prognostic factors for PFS (7.0 months if FAS+ and p53-; 3.4 months if FAS+/p53+ or FAS-/p53-; and 0.7 months if FAS- and p53+; P < .001) and for overall survival. ammonium ferrous sulfate 71-74 tumor protein p53 Homo sapiens 8-11 27185843-10 2016 FAS and p53 were shown to be prognostic factors for PFS (7.0 months if FAS+ and p53-; 3.4 months if FAS+/p53+ or FAS-/p53-; and 0.7 months if FAS- and p53+; P < .001) and for overall survival. ammonium ferrous sulfate 71-74 tumor protein p53 Homo sapiens 8-11 27185843-10 2016 FAS and p53 were shown to be prognostic factors for PFS (7.0 months if FAS+ and p53-; 3.4 months if FAS+/p53+ or FAS-/p53-; and 0.7 months if FAS- and p53+; P < .001) and for overall survival. ammonium ferrous sulfate 71-74 tumor protein p53 Homo sapiens 8-11 21426305-5 2011 Thus, mt p53-R175H may desensitize tumours to Fas-mediated anchorage-independent death via a FAK-dependent mechanism. ammonium ferrous sulfate 46-49 tumor protein p53 Homo sapiens 9-12 24568186-11 2014 When MCF-7 cells were treated with the Fe(2+)-specific chelator phenanthroline, 15d-PGJ2-induced p53 expression was attenuated. ammonium ferrous sulfate 39-45 tumor protein p53 Homo sapiens 97-100 24667498-4 2014 We demonstrated that JMJD6 acts as an alpha-ketoglutarate- and Fe(II)-dependent lysyl hydroxylase to catalyze p53 hydroxylation. ammonium ferrous sulfate 63-69 tumor protein p53 Homo sapiens 110-113 23523585-7 2013 HMJ-38-influenced HUVECs were performed by determining the oxidative stress (ROS production) and ATM/p53-modulated Fas and DR4/DR5 signals that were examined by flow cytometry, Western blotting, siRNA and real-time RT-PCR analyses, respectively. ammonium ferrous sulfate 115-118 tumor protein p53 Homo sapiens 101-104 16844116-1 2006 Ionizing radiation (IR) is known to upregulate cell surface Fas through p53 activation in various cells. ammonium ferrous sulfate 60-63 tumor protein p53 Homo sapiens 72-75 17695548-4 2007 RESULTS: FAS was statistically associated with p53 (p = 0.002), Ki-67 (p = 0.003), higher histological grade (p = 0.001 and recurrence and overall survival (p = 0.001). ammonium ferrous sulfate 9-12 tumor protein p53 Homo sapiens 47-50 21509038-7 2011 Importantly, an analogous Fas-dependent mechanism of apoptosis upon Nutlin-3 treatment is executed in wild-type p53 expressing Hodgkin lymphoma and acute myeloid leukaemia cell lines. ammonium ferrous sulfate 26-29 tumor protein p53 Homo sapiens 112-115 18571879-7 2008 This analysis revealed that DNA damage resulted in changes in splicing activity that modified the splicing pattern of Fas, a key pro-apoptotic, p53-inducible death receptor. ammonium ferrous sulfate 118-121 tumor protein p53 Homo sapiens 144-147 16917513-6 2007 However, we found that Fas/CD95 was significantly induced in response to hypoxia in a p53-dependent manner, along with several novel p53 target genes including ANXA1, DDIT3/GADD153 (CHOP), SEL1L and SMURF1. ammonium ferrous sulfate 23-26 tumor protein p53 Homo sapiens 86-89 16844116-7 2006 These results suggest that IR-induced p53 activation may upregulate cell surface Fas via the down-modulation of FAP-1. ammonium ferrous sulfate 81-84 tumor protein p53 Homo sapiens 38-41 16432159-0 2006 Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide. ammonium ferrous sulfate 42-45 tumor protein p53 Homo sapiens 15-18 16306425-7 2006 Taken together, these data suggest that the TRP53 protein influences the sensitivity of GC-2 cells to undergo FAS-mediated apoptosis by modulating the expression of FAS on their cell membranes and subsequently influencing the degradation of the antiapoptotic protein CFLAR (L). ammonium ferrous sulfate 110-113 tumor protein p53 Homo sapiens 44-49 16432159-8 2006 These data suggest that p53 function for inducing Fas-mediated apoptosis in gliomas, which express sufficient quantities of endogenous mutant or WT p53, may be restored or activated, respectively, by a cell-permeable peptide derived from the p53 COOH-terminal regulatory domain (p53p-Ant). ammonium ferrous sulfate 50-53 tumor protein p53 Homo sapiens 24-27 16432159-8 2006 These data suggest that p53 function for inducing Fas-mediated apoptosis in gliomas, which express sufficient quantities of endogenous mutant or WT p53, may be restored or activated, respectively, by a cell-permeable peptide derived from the p53 COOH-terminal regulatory domain (p53p-Ant). ammonium ferrous sulfate 50-53 tumor protein p53 Homo sapiens 148-151 16432159-8 2006 These data suggest that p53 function for inducing Fas-mediated apoptosis in gliomas, which express sufficient quantities of endogenous mutant or WT p53, may be restored or activated, respectively, by a cell-permeable peptide derived from the p53 COOH-terminal regulatory domain (p53p-Ant). ammonium ferrous sulfate 50-53 tumor protein p53 Homo sapiens 148-151 16432159-8 2006 These data suggest that p53 function for inducing Fas-mediated apoptosis in gliomas, which express sufficient quantities of endogenous mutant or WT p53, may be restored or activated, respectively, by a cell-permeable peptide derived from the p53 COOH-terminal regulatory domain (p53p-Ant). ammonium ferrous sulfate 50-53 tumor protein p53 Homo sapiens 279-283 15161716-0 2004 The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites. ammonium ferrous sulfate 56-59 tumor protein p53 Homo sapiens 38-41 16204068-3 2005 In contrast, irinotecan (CPT-11) and tomudex sensitized p53 WT, mutant, and null cells to Fas-mediated cell death. ammonium ferrous sulfate 90-93 tumor protein p53 Homo sapiens 56-59 15680394-0 2005 Altered trafficking of Fas and subsequent resistance to Fas-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma. ammonium ferrous sulfate 23-26 tumor protein p53 Homo sapiens 101-104 15680394-0 2005 Altered trafficking of Fas and subsequent resistance to Fas-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma. ammonium ferrous sulfate 56-59 tumor protein p53 Homo sapiens 101-104 15680394-9 2005 CONCLUSIONS: These data suggest that decreased cell-surface expression of Fas and resistance to Fas-mediated apoptosis may occur independently of loss of wt p53 expression. ammonium ferrous sulfate 74-77 tumor protein p53 Homo sapiens 157-160 15285929-0 2004 Eicosapentaenoic acid induces Fas-mediated apoptosis through a p53-dependent pathway in hepatoma cells. ammonium ferrous sulfate 30-33 tumor protein p53 Homo sapiens 63-66 15163458-11 2004 CONCLUSIONS: This study provides evidence that redox-active (Fe2+), (Mn2+), (Cu2+), and (Zn2+) ion-induced apoptosis in PBL by (H2O2)/(.OH) generation, resulting in mitochondria depolarization, caspase-3 activation, and nuclear fragmentation independent of NF-kappaB and p53 transcription factors activation. ammonium ferrous sulfate 61-65 tumor protein p53 Homo sapiens 271-274 14987952-6 2004 Besides, HepG2/C3A cells were found to be arrested in G(2)/M phase after the cells were treated with 60 microM emodin for 48 h. Moreover, significant increase in the levels of apoptosis-related signals such as p53 (419.3 pg/ml), p21 (437.4 units/ml), Fas (6.6 units/ml), and caspase-3 (35.4 pmol/min) were observed in emodin treated HepG2/C3A cells. ammonium ferrous sulfate 251-254 tumor protein p53 Homo sapiens 210-213 12963547-3 2003 RESULTS: On exposure to 5 Gy radiation, LNCaP cells demonstrated high sensitization to Fas-mediated apoptosis through increased Fas expression, stabilized p53 expression and binding to p53 response elements within the promoter and first intronic region of the Fas gene. ammonium ferrous sulfate 87-90 tumor protein p53 Homo sapiens 155-158 14623946-0 2004 Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts. ammonium ferrous sulfate 40-43 tumor protein p53 Homo sapiens 33-36 12782597-3 2003 To determine the biological significance of this phenomenon, we analyzed p53 mutants, p53(223Leu) and p53(274Phe), from Fas-resistant prostate carcinoma cell line DU145. ammonium ferrous sulfate 120-123 tumor protein p53 Homo sapiens 73-76 12782597-6 2003 Whereas neither of the two mutants was found to be dominant-negative against wild-type p53, each neutralized the other"s growth-suppressive effects and, in combination, were capable of down-regulating Fas expression and converting Fas-sensitive prostate carcinoma cells PC3 into Fas-resistant ones. ammonium ferrous sulfate 201-204 tumor protein p53 Homo sapiens 87-90 14719118-7 2004 Subsequently, flow cytometric analysis revealed a 2- to 4-fold increase in surface Fas/CD95 expression following Ad-p53 infection in mutant-p53-containing cell lines. ammonium ferrous sulfate 83-86 tumor protein p53 Homo sapiens 116-119 14719118-7 2004 Subsequently, flow cytometric analysis revealed a 2- to 4-fold increase in surface Fas/CD95 expression following Ad-p53 infection in mutant-p53-containing cell lines. ammonium ferrous sulfate 83-86 tumor protein p53 Homo sapiens 140-143 14719118-8 2004 Use of the protein transport inhibitor Brefeldin A significantly inhibited Ad-p53-induced surface Fas/CD95 expression, but only partially inhibited apoptosis in mutant-p53 cell lines. ammonium ferrous sulfate 98-101 tumor protein p53 Homo sapiens 78-81 12794118-9 2003 The wt p53-induced optimization of tumor cell killing by specific CTL involves at least in part Fas-mediated pathway via induction of CD95 expression by tumor cells but does not appear to interfere with granzyme B cytotoxic pathway. ammonium ferrous sulfate 96-99 tumor protein p53 Homo sapiens 7-10 12963547-3 2003 RESULTS: On exposure to 5 Gy radiation, LNCaP cells demonstrated high sensitization to Fas-mediated apoptosis through increased Fas expression, stabilized p53 expression and binding to p53 response elements within the promoter and first intronic region of the Fas gene. ammonium ferrous sulfate 87-90 tumor protein p53 Homo sapiens 185-188 12963547-6 2003 CONCLUSIONS: Radiation-induced Fas sensitization in prostate cancer cell was mediated through p53-dependent transactivation of the Fas gene, which can be blocked by androgen stimulation mainly through induction of c-jun. ammonium ferrous sulfate 31-34 tumor protein p53 Homo sapiens 94-97 12712406-10 2003 CONCLUSIONS: These results suggest that, in p53-mutated prostate cancer, JNK-initiated Fas-mediated apoptotic signals may play an important role in chemosensitivity. ammonium ferrous sulfate 87-90 tumor protein p53 Homo sapiens 44-47 12397013-0 2002 Hydrogen peroxide induces upregulation of Fas in human airway epithelial cells via the activation of PARP-p53 pathway. ammonium ferrous sulfate 42-45 tumor protein p53 Homo sapiens 106-109 12670900-0 2003 Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143. ammonium ferrous sulfate 0-3 tumor protein p53 Homo sapiens 49-52 12670900-0 2003 Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143. ammonium ferrous sulfate 0-3 tumor protein p53 Homo sapiens 117-120 12670900-5 2003 Our results demonstrated that Fas-mediated apoptosis in H1299 and PC-3 cells expressing p53 mutant 143Ala occurred only with the wild-type p53 phenotype. ammonium ferrous sulfate 30-33 tumor protein p53 Homo sapiens 88-91 12670900-5 2003 Our results demonstrated that Fas-mediated apoptosis in H1299 and PC-3 cells expressing p53 mutant 143Ala occurred only with the wild-type p53 phenotype. ammonium ferrous sulfate 30-33 tumor protein p53 Homo sapiens 139-142 12670900-6 2003 These results support the hypothesis that Fas-mediated apoptosis is dependent, at least partially, on the presence of a functional wild-type p53 state. ammonium ferrous sulfate 42-45 tumor protein p53 Homo sapiens 141-144 12538456-7 2003 Quantitative reverse transcription-PCR analysis of the four p53 related genes [p21 (CDKN1A), FAS, BAK, and MDM2] revealed that Bak expression was increased significantly 24 h after Ad-p53 (INGN 201) injection and levels of CDKN1A and MDM2 expression were increased over the course of treatment. ammonium ferrous sulfate 93-96 tumor protein p53 Homo sapiens 60-63 12397013-11 2002 These results indicate that H(2)O(2) induces Fas upregulation by promoting cytoplasmic transport of Fas to the cell surface in human airway epithelial cells, and that the activation of the poly(ADP-ribose) polymerase-p53 pathway may be involved in this mechanism. ammonium ferrous sulfate 45-48 tumor protein p53 Homo sapiens 217-220 11169523-6 2001 A positive correlation between Fas and p53 was demonstrated in RA ST. ammonium ferrous sulfate 31-34 tumor protein p53 Homo sapiens 39-42 11822871-3 2002 Fas-induced apoptosis and ceramide formation proceeded regardless of p53 status. ammonium ferrous sulfate 0-3 tumor protein p53 Homo sapiens 69-72 11599886-0 2001 Fas-independent apoptosis induced by UVC in p53-mutated human epithelial tumor A431 cells through activation of caspase-8 and JNK/SAPK. ammonium ferrous sulfate 0-3 tumor protein p53 Homo sapiens 44-47 10951228-4 2000 Recent evidence has shown that Fas-induced keratinocyte apoptosis in response to ultraviolet light, prevents the accumulation of pro-carcinogenic p53 mutations by deleting ultraviolet-mutated keratinocytes. ammonium ferrous sulfate 31-34 tumor protein p53 Homo sapiens 146-149 11106264-11 2000 Therefore, in colon carcinomas that express wtp53, the approach to sensitize tumors to Fas-mediated apoptosis may be further enhanced from the effect of FUra-LV in elevating Fas expression in a p53-dependent manner. ammonium ferrous sulfate 87-90 tumor protein p53 Homo sapiens 46-49 11106264-11 2000 Therefore, in colon carcinomas that express wtp53, the approach to sensitize tumors to Fas-mediated apoptosis may be further enhanced from the effect of FUra-LV in elevating Fas expression in a p53-dependent manner. ammonium ferrous sulfate 174-177 tumor protein p53 Homo sapiens 46-49 11103825-6 2000 CD437 induced Fas expression in three NSCLC cell lines with wild-type p53 but not in six NSCLC cell lines containing mutant p53. ammonium ferrous sulfate 14-17 tumor protein p53 Homo sapiens 70-73 10096571-4 1999 Fas-mediated cell death in these cell lines is p53-independent. ammonium ferrous sulfate 0-3 tumor protein p53 Homo sapiens 47-50 10389864-14 1999 We have also shown that Fas levels are significantly increased in response to irradiation in a wt p53 line. ammonium ferrous sulfate 24-27 tumor protein p53 Homo sapiens 98-101 10696460-8 2000 In a p53-positive cell line (DU145), p53 was repressed by 70% and Fas elevated sixfold with 10 mM PB. ammonium ferrous sulfate 66-69 tumor protein p53 Homo sapiens 5-8 10421649-6 1999 In Fas-positive HCC cases (n = 15), the intrahepatic metastatic foci was less (P =.037), apoptosis of tumor cells was more (P =.004), the disease-free survival rate was higher (P =.004), and p53-positive cases were less (P =.003), compared with Fas-negative cases. ammonium ferrous sulfate 3-6 tumor protein p53 Homo sapiens 191-194 10080943-3 1999 Here, we report that although Fas induction is closely linked to the expression of wild type p53, it is not correlated with JNK activation induced by apoptotic stimuli. ammonium ferrous sulfate 30-33 tumor protein p53 Homo sapiens 93-96 9823951-15 1998 In contrast, four of five Fas+/Fas-resistant (R) lines were wt-p53+/Bcl-2+; the exception was p53-null/Bcl-2- but expressed a low level of Fas (150 MESF). ammonium ferrous sulfate 26-29 tumor protein p53 Homo sapiens 63-66 9823951-15 1998 In contrast, four of five Fas+/Fas-resistant (R) lines were wt-p53+/Bcl-2+; the exception was p53-null/Bcl-2- but expressed a low level of Fas (150 MESF). ammonium ferrous sulfate 31-34 tumor protein p53 Homo sapiens 63-66 9823951-0 1998 Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression. ammonium ferrous sulfate 15-18 tumor protein p53 Homo sapiens 108-111 9823951-15 1998 In contrast, four of five Fas+/Fas-resistant (R) lines were wt-p53+/Bcl-2+; the exception was p53-null/Bcl-2- but expressed a low level of Fas (150 MESF). ammonium ferrous sulfate 31-34 tumor protein p53 Homo sapiens 63-66 9823951-3 1998 We therefore investigated the relationship between sensitivity to Fas-mediated apoptosis and (1) Fas expression, (2) p53 status, and (3) Bcl-2 protein levels in pediatric ALL cell lines and primary leukemic cells. ammonium ferrous sulfate 66-69 tumor protein p53 Homo sapiens 117-120 9823951-13 1998 Sensitivity to Fas-mediated apoptosis was associated with a mt-p53 phenotype and absence of Bcl-2 expression. ammonium ferrous sulfate 15-18 tumor protein p53 Homo sapiens 63-66 9823951-18 1998 These results suggest that some pediatric ALL cells expressing mt-p53+ may be sensitive to Fas-mediated apoptosis due to high levels of Fas expression and lack of Bcl-2, and further suggest that molecular methods of activating Fas may be useful for therapy of refractory ALL with the Fas+/mt-p53+ phenotype. ammonium ferrous sulfate 91-94 tumor protein p53 Homo sapiens 66-69 9823951-18 1998 These results suggest that some pediatric ALL cells expressing mt-p53+ may be sensitive to Fas-mediated apoptosis due to high levels of Fas expression and lack of Bcl-2, and further suggest that molecular methods of activating Fas may be useful for therapy of refractory ALL with the Fas+/mt-p53+ phenotype. ammonium ferrous sulfate 91-94 tumor protein p53 Homo sapiens 292-295 9458377-5 1998 These findings suggest that Fas-mediated therapy could be a novel approach to RCC, if interferon- treatment is added according to the p53 gene status. ammonium ferrous sulfate 28-31 tumor protein p53 Homo sapiens 134-137 9765154-5 1998 p53 also induced Fas-FADD binding and transiently sensitized cells to Fas-induced apoptosis. ammonium ferrous sulfate 17-20 tumor protein p53 Homo sapiens 0-3 7478511-0 1995 Induction of Fas-mediated apoptosis in p53-transfected human colon carcinoma cells. ammonium ferrous sulfate 13-16 tumor protein p53 Homo sapiens 39-42 9135020-5 1997 Using Western blot analysis, we found abundant expression of p53 in the cytoplasm of two Fas-resistant cell lines, DU145 and ND1, and did not find p53 in two Fas-sensitive cell lines, PC3 and ALVA31. ammonium ferrous sulfate 89-92 tumor protein p53 Homo sapiens 61-64 7478511-7 1995 The findings suggest that a Fas-initiated pathway is incidentally linked to a p53-dependent apoptotic pathway through the reconstituted wild-type p53 gene in WiDr cells. ammonium ferrous sulfate 28-31 tumor protein p53 Homo sapiens 78-81 7478511-7 1995 The findings suggest that a Fas-initiated pathway is incidentally linked to a p53-dependent apoptotic pathway through the reconstituted wild-type p53 gene in WiDr cells. ammonium ferrous sulfate 28-31 tumor protein p53 Homo sapiens 146-149 35513212-3 2022 Here, we constructed a self-assembled metal-organic nanomedicine p53/Ce6@ZF-T, which was composed of p53 plasmid-complexed chlorin e6 (Ce6)-poly(amidoamine), Fe2+-containing mesoporous zeolitic imidazolate framework-8 and naturally derived tannic acid (TA). ammonium ferrous sulfate 158-162 tumor protein p53 Homo sapiens 65-68 35513212-3 2022 Here, we constructed a self-assembled metal-organic nanomedicine p53/Ce6@ZF-T, which was composed of p53 plasmid-complexed chlorin e6 (Ce6)-poly(amidoamine), Fe2+-containing mesoporous zeolitic imidazolate framework-8 and naturally derived tannic acid (TA). ammonium ferrous sulfate 158-162 tumor protein p53 Homo sapiens 101-104 35513212-4 2022 The highly cytotoxic ROS was continuously produced via Fe2+-mediated and TA-assisted enhanced Fenton reaction as well as Ce6-induced photosensitive reaction, and meanwhile, the intratumoral upregulated p53 expression inactivated glutathione peroxidase 4 (GPX4) to suppress lipid peroxidation (LPO) resistance, thus resulting in amplified oxidative stress and intensified ferroptosis-apoptosis therapy. ammonium ferrous sulfate 55-59 tumor protein p53 Homo sapiens 202-205