PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18444250-0	2008	Betulinic acid suppresses constitutive and TNFalpha-induced NF-kappaB activation and induces apoptosis in human prostate carcinoma PC-3 cells.	betulinic acid	0-14	tumor necrosis factor	Homo sapiens	43-51	
30553912-5	2019	In addition, we found that the mRNA expression of IL-1beta, IL-6, IL-8 and IL-17A were markedly down-regulated by treatment with betulinic acid in TNF-alpha-induced RA FLSs.	betulinic acid	129-143	tumor necrosis factor	Homo sapiens	147-156	
30553912-7	2019	The results indicated that betulinic acid treatment reduced the TNF-alpha-induced activation of NF-kappaB signal pathway and the NF-kappaB nuclear accumulation.	betulinic acid	27-41	tumor necrosis factor	Homo sapiens	64-73	
26865097-7	2016	Furthermore, the cell culture studies showed that lupeol and betulinic acid inhibited the PTP1B activity stimulated by TNFalpha in neurons.	betulinic acid	61-75	tumor necrosis factor	Homo sapiens	119-127	
19896462-0	2010	Protective role of betulinic acid on TNF-alpha-induced cell adhesion molecules in vascular endothelial cells.	betulinic acid	19-33	tumor necrosis factor	Homo sapiens	37-46	
19896462-2	2010	In the present study, betulinic acid (BA) treatment was found to show potent inhibitory effect on vascular inflammation process by TNF-alpha in human umbilical vein endothelial cells (HUVEC).	betulinic acid	22-36	tumor necrosis factor	Homo sapiens	131-140	
19896462-2	2010	In the present study, betulinic acid (BA) treatment was found to show potent inhibitory effect on vascular inflammation process by TNF-alpha in human umbilical vein endothelial cells (HUVEC).	betulinic acid	38-40	tumor necrosis factor	Homo sapiens	131-140	
19896462-3	2010	Pretreatment of HUVEC with BA was blocked TNF-alpha induced expression level of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), endothelial cell selectin (E-selectin) as well as gelatinase in TNF-alpha-activated HUVEC in a dose-dependent manner.	betulinic acid	27-29	tumor necrosis factor	Homo sapiens	42-51	
19896462-3	2010	Pretreatment of HUVEC with BA was blocked TNF-alpha induced expression level of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), endothelial cell selectin (E-selectin) as well as gelatinase in TNF-alpha-activated HUVEC in a dose-dependent manner.	betulinic acid	27-29	tumor necrosis factor	Homo sapiens	264-273	
19896462-4	2010	When preincubated with BA, the adhesion of HL-60 cells to TNF-alpha-induced HUVEC was significantly decreased in a concentration-dependent manner.	betulinic acid	23-25	tumor necrosis factor	Homo sapiens	58-67	
19896462-5	2010	TNF-alpha-induced intracellular ROS was markedly decreased by pretreatment with BA.	betulinic acid	80-82	tumor necrosis factor	Homo sapiens	0-9	
19896462-6	2010	Furthermore, BA significantly inhibited the translocation and transcriptional activity of NF-kappaB increased by TNF-alpha.	betulinic acid	13-15	tumor necrosis factor	Homo sapiens	113-122	
26469741-0	2015	Self assembled nano fibers of betulinic acid: A selective inducer for ROS/TNF-alpha pathway mediated leukemic cell death.	betulinic acid	30-44	tumor necrosis factor	Homo sapiens	74-83	
34348637-6	2021	Additionally, triterpene acid mixture (ursolic acid, oleanolic acid, and betulinic acid), also isolated from rosehip, has been reported to reduce the production of interleukin-6 and Tumor necrosis factor-alpha.	betulinic acid	73-87	tumor necrosis factor	Homo sapiens	182-209