PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27748864-2	2016	The antitumor pharmacological effects of BA consist of triggering apoptosis via the mitochondrial pathway, regulating the cell cycle and the angiogenic pathway via factors, including specificity protein transcription factors, cyclin D1 and epidermal growth factor receptor, inhibiting the signal transducer and activator of transcription 3 and nuclear factor-kappaB signaling pathways, preventing the invasion and metastasis of tumor cells, and affecting the expression of topoisomerase I, p53 and lamin B1.	betulinic acid	41-43	epidermal growth factor receptor	Homo sapiens	240-272	
20407012-2	2010	Betulinic acid (BA) and curcumin inhibited bladder cancer cell growth and downregulated specificity protein (Sp) transcription factors, and this was accompanied by decreased expression of EGFR mRNA and protein levels.	betulinic acid	0-14	epidermal growth factor receptor	Homo sapiens	188-192	
20407012-2	2010	Betulinic acid (BA) and curcumin inhibited bladder cancer cell growth and downregulated specificity protein (Sp) transcription factors, and this was accompanied by decreased expression of EGFR mRNA and protein levels.	betulinic acid	16-18	epidermal growth factor receptor	Homo sapiens	188-192	
20407012-4	2010	BA, curcumin, and iSp also decreased phosphorylation of Akt in these cells, and downregulation of EGFR by BA, curcumin, and iSp was accompanied by induction of LC3 and autophagy, which is consistent with recent studies showing that EGFR suppresses autophagic cell death.	betulinic acid	0-2	epidermal growth factor receptor	Homo sapiens	98-102	
20407012-4	2010	BA, curcumin, and iSp also decreased phosphorylation of Akt in these cells, and downregulation of EGFR by BA, curcumin, and iSp was accompanied by induction of LC3 and autophagy, which is consistent with recent studies showing that EGFR suppresses autophagic cell death.	betulinic acid	0-2	epidermal growth factor receptor	Homo sapiens	232-236	
20407012-5	2010	The results show that EGFR is an Sp-regulated gene in bladder cancer, and drugs such as BA and curcumin that repress Sp proteins also ablate EGFR expression.	betulinic acid	88-90	epidermal growth factor receptor	Homo sapiens	22-26	
20407012-5	2010	The results show that EGFR is an Sp-regulated gene in bladder cancer, and drugs such as BA and curcumin that repress Sp proteins also ablate EGFR expression.	betulinic acid	88-90	epidermal growth factor receptor	Homo sapiens	141-145	
20407012-6	2010	Thus, compounds such as curcumin and BA that downregulate Sp transcription factors represent a novel class of anticancer drugs that target EGFR in bladder cancer cells and tumors by inhibiting receptor expression.	betulinic acid	37-39	epidermal growth factor receptor	Homo sapiens	139-143	
34961887-0	2021	In silico studies of interactions of peptide-conjugated cholesterol metabolites and betulinic acid with EGFR, LDR, and N-terminal fragment of CCKA receptors.	betulinic acid	84-98	epidermal growth factor receptor	Homo sapiens	104-108	
30136359-0	2018	Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells.	betulinic acid	26-40	epidermal growth factor receptor	Homo sapiens	54-58	
16077934-0	2005	Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid.	betulinic acid	143-157	epidermal growth factor receptor	Homo sapiens	24-28	
16077934-7	2005	The results showed that BA induced EGFR tyrosine phosphorylation in a time-dependent manner.	betulinic acid	24-26	epidermal growth factor receptor	Homo sapiens	35-39	
16077934-10	2005	Pretreatment of EGFR inhibitor PD153035 blocked BA-induced EGFR phosphorylation, ERK and AKT activation, and survivin expression.	betulinic acid	48-50	epidermal growth factor receptor	Homo sapiens	16-20	
16077934-10	2005	Pretreatment of EGFR inhibitor PD153035 blocked BA-induced EGFR phosphorylation, ERK and AKT activation, and survivin expression.	betulinic acid	48-50	epidermal growth factor receptor	Homo sapiens	59-63	
16077934-12	2005	Collectively, we conclude that betulinic acid transiently activated the EGFR/AKT cell survival pathway and induced survivin expression, contributing to less sensitivity in human melanoma cells.	betulinic acid	31-45	epidermal growth factor receptor	Homo sapiens	72-76